Abstract: This study explored the clinical value of ultrasound combined with serum carbohydrate antigen 125 (CA125) and human epididymal protein 4 (HE4) in ovarian sex cord stromal tumors (OSCST). Selected 87 OSCST patients (OSCST group) and 90 patients (control group) with benign ovarian cysts confirmed by postoperative pathological examination, and analyzed the preoperative transvaginal color doppler ultrasound (CDFI) imaging characteristics and serum CA125 and HE4 levels (determined by chemiluminescence method) of the two groups. The diagnostic value of each index was analyzed by receiver operator characteristic (ROC) curve. The results showed that the levels of serum CA125 and HE4 in the OSCST group were significantly higher than those in the control group (P＜0.05). The echo attenuation behind the lesions in the OSCST group was more significant than that in the control group (P<0.05). The CDFI blood flow of the lesions in the OSCST group the grade Ⅱ and grade Ⅲ patients in the classification was higher than those in the control group (P<0.05). The sensitivity of ultrasound combined with serum CA125 and HE4 in the differential diagnosis of OSCST and benign ovarian cysts was 85.06%, specificity was 80.00%, missed diagnosis rate was 14.94%, and misdiagnosis rate was 20.00%. Ultrasound combined with serum CA125 and HE4 in the differential diagnosis of OSCST and ovarian benign cysts has higher clinical sensitivity and specificity. Compared with the three methods alone, it can significantly improve the accuracy of diagnosis.

Key words: transvaginal color Doppler ultrasound, carbohydrate antigen, human epididymal protein 4, ovarian sex cord stromal tumors