Evaluation of DKI Combined with DWI Quantitative Indicators in the Pathological Characteristics of HCC and the Efficacy of TACE

doi:10.7517/issn.1674-0475.220120

Abstract

Abstract: This study investigated the value of quantitative indicators of diffusion kurtosis imaging (DKI) and diffusion weighted imaging (DWI) in assessing the pathological characteristics of hepatocellular carcinoma (HCC) and evaluating the therapeutic effect of transcatheter arterial chemoembolization (TACE). Selected 98 confirmed HCC patients as the case group,and 100 patients with benign liver tumors as the control group. Compared the DKI and DWI quantitative parameters of the two groups of patients, as well as the differences of DKI and DWI parameters in HCC patients with different tumor differentiation and microvascular invasion, all the above parameters were used to evaluate the effect of TACE in the treatment of HCC. The results showed the mean diffusivity (MD), mean kurtosis (MK) and apparent diffusion coefficient (ADC) values of patients in the case group were lower than those in the control group (P<0.05). The AUC value of MD, MK, ADC to differentially diagnose liver benign and malignant tumors was 0.734, 0.857, 0.898, respectively. The MD, MK and ADC values of HCC patients in (Ⅰ+Ⅱ) stage were higher than those of HCC patients in (Ⅲ+Ⅳ) stage (P<0.05). MD, MK and ADC values in HCC patients with microvascular invasion were all lower than those of HCC patients without microvascular invasion (P<0.05). The values of MD, MK and ADC in the lesions tissue of HCC patients after TACE were higher than those of lesion tissue before TACE (P<0.05). The quantitative parameters of magnetic resonance DKI and DWI have a high value in the differential diagnosis of benign and malignant liver tumors, especially the ADC value. At the same time, they could effectively evaluate the changes of lesion tissue after TACE treatment of HCC.

Key words: magnetic resonance, diffusion kurtosis imaging, diffusion weighted imaging, hepatocellular carcinoma, transcatheter arterial chemoembolization

GUO Yonggang, DU Ying, YE Pengfei. Evaluation of DKI Combined with DWI Quantitative Indicators in the Pathological Characteristics of HCC and the Efficacy of TACE[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 768-772.

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