SOLUBLE FLUOROALKOXYL METAL PHTHALOCYANATE:NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC TUMOR THERAPY

doi:10.7517/j.issn.1674-0475.2001.04.244

Abstract

Abstract: Novel polyfluoroalkoxyl metal phthalocyanates were synthesized,which were soluble in most organic solvents.The photooxygenation and photocleavage to DNA showed that zinc and aluminum phthalocyanates have efficient action to generate singlet oxygen.2a in presence of emulsifying agent F68 displays a good photocytotoxicity in vitro on myeloma cells under the irradiation of red light.

Key words: phthalocyanine, synthesis, photosensitizer, DNA photocleavage, photocytotoxicity

CLC Number:

0644

GAO Lin-dong, QIAN Xu-hong, ZHANG Yuan-xing, ZHANG Li. SOLUBLE FLUOROALKOXYL METAL PHTHALOCYANATE:NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC TUMOR THERAPY[J]. Imaging Science and Photochemistry, 2001, 19(4): 244-249.

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