IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (6): 1570-1575.DOI: 10.7517/issn.1674-0475.220717

• Review and Articles • Previous Articles     Next Articles

Application of 18F-FDG PET/CT Metabolic Parameters Combined with Serum FOXM1 in the Diagnosis of Lymph Node Metastasis in Colorectal Cancer

WANF Ping1, XIE Lixuan2   

  1. 1. Medical and Nursing School, Wuhan Railway Vocational College of Technology, Wuhan 430200, Hubei, P. R. China;
    2. Central Theater General Hospital of the Chinese People's Liberation Army, Wuhan 430070, Hubei, P. R. China
  • Received:2022-07-15 Online:2022-11-23 Published:2022-11-15

Abstract: This study investigated the value of 18F-fluorodeoxyglucose (FDG) positron emission/computed tomography (PET/CT) metabolic parameters combined with serum forkhead box protein M1 (FOXM1) in the diagnosis of lymph node metastasis of colorectal cancer. A total of 103 patients with colorectal cancer were included in this study, and the lymph node metastasis was confirmed by pathological examination, and then the patients were divided into the metastasis group (51 cases) and the non-metastasis group (52 cases). All patients underwent 18F-FDG PET/CT examination, and then three metabolic parameters of maximum normalized uptake value (SUVmax), total glycolysis (TLG) and tumor metabolic volume (MTV) were obtained. In addition, serum FOXM1 levels of patients were detected by the ELISA method. The results showed that the SUVmax of non-metastasis was significantly higher than that of metastasis group (P<0.001). The MTV and TLG of the non-metastatic group was significantly lower than that of the metastatic group (P<0.001). Serum FOXM1 in the non-metastatic group was significantly lower than that in the metastatic group (P<0.001). Serum FOXM1 was significantly negatively correlated with SUVmax (P<0.01), while significantly positively correlated with MTV and TLG (P<0.01). The AUC (0.974) and sensitivity (92.16%) of SUVmax+MTV+TLG+serum FOXM1 in the diagnosis of lymph node metastasis were higher than those of 18F-FDG PET/CT metabolic parameters and serum FOXM1 alone, and the specificity (94.23%) was only lower than that of TLG alone. The three metabolic parameters (SUVmax, MTV and TLG) of 18F-FDG PET/CT combined with serum FOXM1 have high value in the diagnosis of lymph node metastasis.

Key words: colorectal cancer, 18F-FDG PET/CT, metabolic parameters, forkhead box protein M1, lymph node metastasis