Value of Multi-slice Spiral CT Perfusion Imaging in Evaluating Interventional Thermochemotherapy for Advanced Hepatocellular Carcinoma

doi:10.7517/issn.1674-0475.190909

Abstract

Abstract: To investigate the application value of multi-slice spiral CT perfusion imaging (CTPI) in evaluating the efficacy of interventional thermal chemotherapy in the treatment of advanced liver cancer, we analyzed the CTPI perfusion parameters and serum oncology markers of 72 patients with middle and advanced liver cancer before and after interventional thermochemotherapy treatment. Compared with the data before treatment, it was found that the perfusion parameters of CTPI in the cancer foci were significantly improved after treatment, and the serum tumor markers were significantly decreased. The CTPI perfusion parameters and serum tumor markers showed statistically significant differences between the complete lipiodol depositon group and partial lipiodol depositon group, the same as between the objective remission group and non-remission group. Pearson correlation analysis showed a significant correlation between CTPI perfusion parameters and serum tumor markers of liver cancer patients. In conclusion, CTPI perfusion parameters can effectively reflect arterial blood supply changes in patients with advanced liver cancer before and after interventional thermal chemotherapy, providing a valuable reference for clinical efficacy evaluation.

Key words: multi-slice spiral CT perfusion imaging, interventional thermochemotherapy, liver cancer, objective remission, AFP, VEGF, MMP-9

CLC Number:

CHEN Tingyu, WANG Tao, GONG Qiyun, WANG Heng, ZHANG Hongwei. Value of Multi-slice Spiral CT Perfusion Imaging in Evaluating Interventional Thermochemotherapy for Advanced Hepatocellular Carcinoma[J]. Imaging Science and Photochemistry, 2020, 38(2): 272-279.

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