Abstract: In this research, 108 patients with epileptic seizures in our hospital were selected as the research group, 82 healthy subjects were included as the control group. All of them were received 3D-ASL perfusion imaging, as well as serum homocysteine (Hcy) and neuropeptide (NPY) level detection. It was found that the cerebral blood flow (CBF) and mini-mental state examination (MMSE) scores of the study group were lower than those of the control group, and the serum Hcy and NPY levels were higher than that of the control group (P<0.05). There was a certain correlation between CBF, Hcy, NPY and seizure type, EEG characteristics in patients with epileptic seizures (P<0.05). The course of disease, frequency of seizures, type of seizures, epileptic discharge, duration of seizures, type of medication, history of status epilepticus, education level, Hcy, NPY, CBF were all the important influencing factors of cognitive impairment in epilepsy (P<0.05). It can be seen that early joint detection of 3D-ASL perfusion imaging, serum Hcy and NPY can provide evidence-based guidance for clinical diagnosis and treatment for epilepsy, as well as the assessment of disease severity and improvement of prognosis.

Key words: three-dimensional arterial spin labeling technique perfusion imaging, homocysteine, neuropeptide Y, epilepsy