Study on the Difference of MicroRNA Expression in Lavage Fluid of Virtual Navigation Ultrasound Bronchoscopy in Patients with Different Types of Lung Cancer and the Diagnostic Efficacy in Peripheral Lung Cancer

doi:10.7517/issn.1674-0475.200817

Abstract

Abstract: This study aimed to investigate the differences in the expression of microRNA (miRNA) in lavage fluid of virtual navigation ultrasound bronchoscopy in patients with different types of lung cancer and the diagnostic efficacy in peripheral lung cancer (PLC). There were 65 patients with central lung cancer (CLC) (central group) and 65 patients with PLC (peripheral group) who were selected. The expressions of miR-1260b, miR-135a-3p, miR-299-3p, miR-3175 in lavage fluid were detected, as well as the expression of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE). The miR-1260b of the peripheral group was lower than that of the central group, and the miR-135a-3p and miR-3175 were higher than that of the central group (P<0.05). miR-1260b, miR-135a-3p, miR-3175 were related to CEA and NSE, and significantly related to PLC (P<0.05). The AUC of miR-1260b and miR-135a-3p combined diagnosis of PLC was higher than that of single diagnosis. The combined diagnosis efficiency of miR-1260b, miR-135a-3p, miR-299-3p, and miR-3175 was higher than any single one. Therefore, it can be seen that miR-1260b, miR-135a-3p, and miR-3175 in the lavage fluid of virtual navigation ultrasound bronchoscope for PLC and CLC patients are differentially expressed. Combined detection is of great value for the diagnosis of PLC. In addition, the combined detection of miR-1260b, miR-135a-3p, miR-299-3p, and miR-3175 can predict PLC metastasis and provide a basis for clinical diagnosis and treatment.

Key words: virtual bronchoscopy navigation, bronchial ultrasound guide sheath, peripheral lung cancer, central lung cancer, lavage fluid, microRNA

YAN Jingjing, CAI Qingbo, GUO Fengrui, LIU Ying, ZHANG Ye. Study on the Difference of MicroRNA Expression in Lavage Fluid of Virtual Navigation Ultrasound Bronchoscopy in Patients with Different Types of Lung Cancer and the Diagnostic Efficacy in Peripheral Lung Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(2): 273-279.

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