结肠镜联合CEA、CA242鉴别结直肠息肉与癌变的效能研究

doi:10.7517/issn.1674-0475.200911

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (2): 280-285.DOI: 10.7517/issn.1674-0475.200911

结肠镜联合CEA、CA242鉴别结直肠息肉与癌变的效能研究

罗雄¹, 夏于新², 孙晓梅¹, 李明月¹, 王柯涵¹, 吴诚³

1. 北京核工业医院内科, 北京 100045;
2. 北京电力医院急诊科, 北京 100073;
3. 中国人民解放军总医院消化科, 北京 100853

收稿日期:2020-09-25 出版日期:2021-03-15 发布日期:2021-03-12
通讯作者: 罗雄

Study on the Efficacy of Colonoscopy Combined with CEA and CA242 in Identifying Colo-rectal Polyps and Cancer

LUO Xiong¹, XIA Yuxin², SUN Xiaomei¹, LI Mingyue¹, WANG Kehan¹, WU Cheng³

1. Department of Internal Medicine, Beijing Nuclear Industry Hospital, Beijing 100045, P. R. China;
2. Emergency Department, Beijing Electric Power Hospital, Beijing 100073, P. R. China;
3. Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, P. R. China

Received:2020-09-25 Online:2021-03-15 Published:2021-03-12

摘要/Abstract

摘要： 本文探讨了通过结肠镜评估病灶直径、病灶数量，联合癌胚抗原（CEA）、糖类抗原242（CA242）鉴别结直肠息肉与癌变的效能。选取2018年1月~2020年1月212例结直肠癌患者作为观察组，另选取同期收治的100例结直肠息肉患者作为对照组。比较两组患者的临床资料、病灶直径、病灶数量和CEA、CA242表达水平，发现将年龄、家族结直肠癌史等因素控制后，病灶直径、病灶数量、腺瘤性病灶、CEA、CA242表达仍与结直肠癌显著相关（P<0.05）；各指标联合鉴别诊断结直肠癌的AUC为0.870，大于任一单一指标（P<0.05）。因此结肠镜下病灶直径、病灶数量、病理类型与CEA、CA242表达水平有关，均是结直肠癌发病的相关影响因素，联合检测各指标有望为诊断鉴别结直肠息肉与结直肠癌提供一个新途径。

关键词: 结肠镜, 病灶直径, 病灶数量, CEA, CA242, 结肠息肉, 结直肠癌

Abstract: The purpose of this study was to investigate the efficacy of colonoscopy in evaluating the diameter and number of lesions combined with carcinoembryonic antigen (CEA) and carbohydrate antigen 242 (CA242) in the identification of colo-rectal polyps and cancer. From January 2018 to January 2020, 212 patients with colo-rectal cancer were selected as the observation group, and 100 patients with colo-rectal polyps during the same period were selected as the control group. The clinical data, the diameter of the lesion, the number of lesions, the expression of CEA and CA242 were compared between the two groups. It was found that after controlling for factors such as age and family history, lesion diameter, number of lesions, adenomatous lesions, CEA and CA242 expression were still significantly correlated with colo-rectal cancer (P<0.05). The AUC of the combined differential diagnosis of colo-rectal cancer was 0.870, which was greater than any single index (P<0.05). Therefore, the diameter, number of lesions and pathological types of colonoscopy are related to the expression levels of CEA and CA242, which are related factors in the incidence of colo-rectal cancer. The combined detection of various indicators is expected to provide a new method for the diagnosis and differentiation of colo-rectal polyps and cancer.

Key words: colonoscopy, lesion diameter, number of lesions, CEA, CA242, colon polyp, colo-rectal cancer

罗雄, 夏于新, 孙晓梅, 李明月, 王柯涵, 吴诚. 结肠镜联合CEA、CA242鉴别结直肠息肉与癌变的效能研究[J]. 影像科学与光化学, 2021, 39(2): 280-285.

LUO Xiong, XIA Yuxin, SUN Xiaomei, LI Mingyue, WANG Kehan, WU Cheng. Study on the Efficacy of Colonoscopy Combined with CEA and CA242 in Identifying Colo-rectal Polyps and Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(2): 280-285.

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结肠镜联合CEA、CA242鉴别结直肠息肉与癌变的效能研究

Study on the Efficacy of Colonoscopy Combined with CEA and CA242 in Identifying Colo-rectal Polyps and Cancer

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