多层螺旋CT联合miR-142-5p对宫颈癌淋巴结转移的诊断分析

doi:10.7517/issn.1674-0475.220132

摘要/Abstract

摘要： 本文主要分析了多层螺旋CT联合miR-142-5p对宫颈癌淋巴结转移的诊断价值。选取疑似宫颈癌淋巴结转移的125例患者作为研究对象，将70例确诊为淋巴结转移的患者作为研究组，55例非淋巴结转移的患者作为对照组。两组均经多层螺旋CT检查，通过实时荧光定量法检测两组miR-142-5p表达量。结果发现，与对照组相比，研究组血容量（BV）、灌注值（PF）、强化峰值（PEI）参数升高，达峰时间（TTP）、miR-142-5p表达量降低，且研究组中淋巴结转移距离≥1.0 cm患者BV、PF、PEI参数最高，TTP参数、miR-142-5p表达量最低（P<0.05）。BV、TTP、PF、PEI、miR-142-5p与不同淋巴结转移距离相关，且BV、TTP、PF、PEI与miR-142-5p相关。BV、TTP、PF、PEI、miR-142-5p联合检测对宫颈癌淋巴结转移的诊断价值较高，ROC曲线下面积（AUC）为0.827（P<0.05）。多层螺旋CT联合miR-142-5p对宫颈癌淋巴结转移有较高的诊断价值，具有一定的临床推广价值。

关键词: 宫颈癌, 淋巴结转移, 多层螺旋CT, 微小RNA-142-5p

Abstract: This paper mainly analyzed the diagnostic value of multilayer spiral CT combined with miR-142-5p for cervical cancer lymph node metastasis. 125 patients with suspected cervical cancer lymph node metastasis were selected as study subjects, 70 patients with confirmed lymph node metastasis were assigned as the study group and 55 patients with non-lymph node metastasis as the control group. Both groups were examined by multicoil CT and the expression of miR-142-5p was determined by real-time fluorescence. The results showed that compared with the control group, the blood volume (BV), perfusion value (PF), peak enhancement (PEI) parameters of the study group increased, while the time to peak (TTP) and the expression of miR-142-5p decreased. The parameters of BV, PF, and PEI were the highest in patients with lymph node metastasis ≥ 1.0 cm, and the expression of TTP parameters and miR-142-5p were the lowest (P<0.05). The BV, TTP, PF, PEI, miR-142-5p were related to different lymph node metastasis distances, and BV, TTP, PF, PEI were related to miR-142-5p. The combination test of BV, TTP, PF, PEI, and miR-142-5p had a high diagnostic value for cervical cancer lymph node metastasis, the area under the curve of ROC was 0.827 (P<0.05). In summary, multi-slice spiral CT combined with miR-142-5p has a high diagnostic value for cervical cancer lymph node metastasis, and has a certain clinical promotion value.

Key words: cervical cancer, lymph node metastasis, multi-slice spiral CT, miR-142-5p

姚玉洁, 杜春玲, 刘雅宁, 张钗. 多层螺旋CT联合miR-142-5p对宫颈癌淋巴结转移的诊断分析[J]. 影像科学与光化学, 2022, 40(4): 902-906.

YAO Yujie, DU Chunling, LIU Yaning, ZHANG Chai. Diagnostic Analysis for Multi-slice Spiral CT Combined with miR-142-5p in Diagnosis of Cervical Cancer Lymph Node Metastasis[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 902-906.

参考文献

[1] Chaichian S, Shafabakhsh R, Mirhashemi S M, et al. Circular rnas:A novel biomarker for cervical cancer[J]. Journal of Cellular Physiology, 2020,235(2):718-724.
[2] Feng C H, Mell L K, Sharabi A B, et al. Immunotherapy with radiotherapy and chemoradiotherapy for cervical cancer[J]. Seminars in Radiation Oncology, 2020,30(4):273-280.
[3] Nahand J S, Taghizadeh-Boroujeni S, Karimzadeh M, et al. microRNAs:New prognostic, diagnostic, and therapeutic biomarkers in cervical cancer[J]. Journal of Cellular Physiology, 2019,234(10):17064-17099.
[4] 陈庭宇, 王涛, 龚齐云, 等. 多层螺旋CT灌注成像评价介入性热化疗治疗中晚期肝癌的价值[J]. 影像科学与光化学, 2020,38(2):272-279.
[5] 王博奇, 孔莹, 李小芳, 等. miR-142-3p介导HMGB1对肝癌细胞增殖、迁移和侵袭的影响[J]. 临床和实验医学杂志, 2020,19(23):2494-2498.
[6] 中国抗癌协会妇科肿瘤专业委员会. 宫颈癌诊断与治疗指南(第4版)[J].中国实用妇科与产科杂志, 2018,34(6):41-50.
[7] 侯丽娟, 王文文, 翟建军, 等. 血清HIF-1α、DcR3、TSGF在宫颈癌诊断中的作用及其与患者临床病理参数的关系[J]. 山东医药, 2021,61(11):52-55.
[8] 胥琳琳, 陈宗宁, 崔蕾蕾, 等. 血清miR-501和miR-195检测对宫颈癌临床诊断及预后价值[J]. 中国计划生育学杂志, 2019,27(12):1690-1692, 1696.
[9] 张冬雅, 郭红军. 18F-FDG PET-CT联合血清SCC-Ag检测对宫颈癌盆腔淋巴结转移的诊断价值[J]. 中国CT和MRI杂志, 2019,17(3):105-108, 153.
[10] 冯彪, 张婉, 郭长义, 等. 多普勒彩超与螺旋CT对宫颈癌淋巴结转移的诊断效能[J]. 实用癌症杂志, 2019,34(9):1448-1450.
[11] 杜鉴铭, 冯硕, 王丹石, 等. 多层螺旋CT联合血清因子对肺癌淋巴结转移老年患者的诊断[J]. 国际老年医学杂志, 2021,42(4):208-212.
[12] 张培栋, 凌鑫, 王敏杰. 多层螺旋CT在喉癌及喉咽癌颈部淋巴结转移中的诊断价值[J]. 癌症进展, 2019,17(19):2333-2335.
[13] 李侠, 肖维. 多层螺旋CT联合血清MMP-2、MMP-9在宫颈癌淋巴结转移诊断中的价值分析[J]. 中国CT和MRI杂志, 2021,19(9):108-110.
[14] 田成斌, 史晓光, 曹辉, 等. 影像学研究在预测宫颈癌盆腔淋巴结转移中的价值[J]. 中国CT和MRI杂志, 2021,19(4):123-126.
[15] 刘东升, 石凯. 多层螺旋CT检查诊断胃底贲门癌的价值[J]. 河南医学研究, 2020,29(36):6858-6860.
[16] 孙沙沙, 李玉华. miR-142-3p对子宫内膜癌细胞增殖、迁移及侵袭的影响[J]. 实用医药杂志, 2020,37(8):736-739, 769.
[17] 彭俊付, 王振彪, 彭继升, 等. miR-142-3p靶向Wnt/β-链蛋白通路对结直肠癌细胞增殖的影响[J]. 临床误诊误治, 2021,34(4):81-86.
[18] 苏红娥, 钟庆吉, 符春丽, 等. 血清miR-153和miR-142-3p表达在宫颈癌诊断和预后评估中的价值[J]. 肿瘤学杂志, 2020,26(11):972-976.
[19] 陆晓云, 张斌, 佟芳. miR-142-3p表达对卵巢癌SKOV3细胞生长和转移的影响[J]. 中国医科大学学报, 2019,48(9):817-821.
[20] 樊阳阳, 王影, 袁峰, 等. MALAT1靶向miR-142-3p在卵巢癌化疗耐药中的机制研究[J]. 国际肿瘤学杂志, 2020,47(2):82-89.
[21] 张智成, 杨清泉. LncRNA-MALAT1通过miR-142-3p/TEAD1分子轴调控结直肠癌细胞增殖与凋亡[J]. 天津医药, 2020,48(12):1146-1152.