关键词: 先天性心脏病, 多层螺旋CT, 心脏超声, 迪乔治综合征危象区基因8, 心肌钙蛋白T

Abstract: This paper analyzed the diagnostic value of multilayer spiral CT, ultrasound combined with serum DiGeorge syndrome crisis region gene 8 (DGCR8) and Cardiac troponin T (cTnT) in children with congenital heart disease. Selecting 90 children with suspected congenital heart disease, and the surgical pathological diagnosis was taken as the "gold standard", then the 60 cases diagnosed with congenital heart disease were set as the study group, and 30 non-congenital heart disease were set as the control group. Multi-slice spiral CT and echocardiography were performed in both groups, and the expression of DGCR8 and the level of cTnT in the two groups were detected. The diagnostic coincidence rate of congenital heart disease subtype was higher than that of the single detection of cardiac ultrasound and multilayer spiral CT (P<0.05). Compared with the control group the study group had lower DGCR8 expression and higher cTnT levels (P<0.05). Children with middle-grade congenital heart disease with different NYHA cardiac function grades had the lowest DGCR8 expression and the highest cTnT level (P<0.05). Correlation analysis showed that DGCR8 and cTnT were related to different severity of illness in the study group (P<0.05). The specificity and sensitivity of the four combinations for the diagnosis of congenital heart disease were 96.67% and 70.00%, respectively (P<0.05). Multilayer spiral CT, cardiac ultrasound combined with serum DGCR8 and cTnT have high diagnostic value for congenital heart disease, which can provide some reference for the formulation of surgical plan for children with congenital heart disease.

Key words: congenital heart disease, multidetector computed tomography, cardiac ultrasound, DiGeorge syndrome crisis region gene 8, cardiac troponin T