脑脊液CD64、血清炎性因子联合MRI对术后继发性神经系统感染的诊断分析

doi:10.7517/issn.1674-0475.221002

摘要/Abstract

摘要： 本文研究脑脊液CD64、血清炎性因子水平联合MRI增强扫描对术后继发性神经系统感染的诊断价值。选取75例神经外科手术后出现脑膜炎的患者，比较细菌性脑膜炎和无菌性脑膜炎患者脑脊液CD64和血清降钙素原（PCT）、C反应蛋白（CRP）水平，以及MRI征象的差异。脑脊液CD64和血清PCT、CRP鉴别诊断细菌性脑膜炎的ROC曲线下面积（AUC）依次为0.949、0.925和0.874。细菌性脑膜炎和无菌性脑膜炎患者MRI征象有所差异（P<0.05）。与MRI增强扫描单独诊断相比较，脑脊液CD64和血清PCT、CRP联合MRI增强扫描诊断细菌性脑膜炎的灵敏性有所提高，但差异无统计学意义（P>0.05）。脑脊液CD64和血清PCT、CRP联合MRI增强扫描鉴别诊断术后继发性神经系统感染有一定的应用价值，值得进一步研究。

关键词: 脑脊液, CD64, 血清, 磁共振成像, 细菌性脑膜炎, 无菌性脑膜炎

Abstract: This paper explored the diagnostic value of cerebrospinal fluid CD64 and serum inflammatory factor levels combined with enhanced MRI in postoperative secondary nervous system infection. Selected 75 patients with meningitis after neurosurgery, and compared the levels of cerebrospinal fluid CD64, serum procalcitonin (PCT), C-reactive protein (CRP) and the differences of MRI signs between bacterial meningitis and aseptic meningitis patients. The area under the ROC curve(AUC) of cerebrospinal fluid CD64, serum PCT and CRP in differential diagnosis of bacterial meningitis were 0.949, 0.925 and 0.874, respectively. The MRI signs of bacterial meningitis and aseptic meningitis were different (P<0.05). Compared with MRI enhanced scan alone, the sensitivity of cerebrospinal fluid CD64, serum PCT, CRP combined with enhanced scan in the diagnosis of bacterial meningitis was improved, but there were no statistically significant difference (P>0.05). Cerebrospinal fluid CD64, serum PCT and CRP combined with MRI enhanced scanning have certain application value in the differential diagnosis of postoperative secondary nervous system infection, which is worthy for further study.

Key words: cerebrospinal fluid, CD64, serum, magnetic resonance imaging, bacterial meningitis, aseptic meningitis

袁永睿, 李争民, 王长平. 脑脊液CD64、血清炎性因子联合MRI对术后继发性神经系统感染的诊断分析[J]. 影像科学与光化学, 2023, 41(1): 119-123.

YUAN Yongrui, LI Zhengmin, WANG Changping. Diagnostic Analysis of Cerebrospinal Fluid CD64, Serum Inflammatory Factors Combined with MRI in Postoperative Secondary Nervous System Infection[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 119-123.

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