药物治疗前后RA患者DCE-MRI参数变化及对骨侵蚀情况的影响

doi:10.7517/issn.1674-0475.221034

影像科学与光化学 ›› 2023, Vol. 41 ›› Issue (1): 136-141.DOI: 10.7517/issn.1674-0475.221034

药物治疗前后RA患者DCE-MRI参数变化及对骨侵蚀情况的影响

郑奕¹, 江迎春¹, 杨豪³, 董战军¹, 陈艳¹, 李思强²

1. 黄淮学院医学院, 河南驻马店 463000;
2. 黄淮学院生物与食品工程学院, 河南驻马店 463000;
3. 驻马店市中心医院, 河南驻马店 463000

收稿日期:2022-10-24 出版日期:2023-01-23 发布日期:2023-01-31
通讯作者: 李思强
基金资助:
河南省自然科学基金（212300410203）、黄淮学院高级人才引进项目（1000.12.01.1678）、黄淮学院国家级项目培育基金（1000.11.07.1678.1002）和黄淮学院横向项目（160116785004）

Changes of DCE-MRI Parameters in RA Patients Before and After Drug Treatment and Its Effect on Bone Erosion

ZHENG Yi¹, JIANG Yingchun¹, YANG Hao³, DONG Zhanjun¹, CHEN Yan¹, LI Siqiang²

1. School of Medical, Huanghuai University, Zhumadian 463000, Henan, P. R. China;
2. School of Biological and Food Processing Engineering, Huanghuai University, Zhumadian 463000, Henan, P. R. China;
3. Zhumadian Central Hospital, Zhumadian 463000, Henan, P. R. China

Received:2022-10-24 Online:2023-01-23 Published:2023-01-31

摘要/Abstract

摘要： 本文探究类风湿关节炎（RA）药物治疗前后动态增强磁共振成像（DCE-MRI）定量参数变化及对骨侵蚀情况的影响。选取112例RA患者，于药物治疗前后行DCE-MRI检查测量定量参数[最大增强（Emax）、最大相对增强（REmax）、相对增强（RE）、最大强化斜率（Slopemax）]，比较有反应和无反应患者治疗前后DCE-MRI定量参数、骨侵蚀评分。结果显示，无反应者治疗前、治疗后Emax、REmax、RE、Slopemax均高于有反应者，治疗前后Emax、REmax、RE、Slopemax变化值均低于有反应者（P<0.05）。治疗前后Emax、REmax、RE、Slopemax变化值均与RA患者药物治疗反应性呈正相关（P<0.05）。治疗前Emax、REmax、RE、Slopemax联合预测RA药物治疗反应性为无反应的曲线下面积（AUC）为0.901（95% CI：0.830～0.949）。无反应者治疗前、治疗后骨侵蚀评分均高于有反应者，治疗前后骨侵蚀评分变化值低于有反应者（P<0.05）。治疗前后Emax、REmax、RE、Slopemax变化值均与RA患者骨侵蚀评分变化值呈正相关（P<0.05）。可见，治疗前DCE-MRI定量参数Emax、REmax、RE、Slopemax能预测RA药物治疗反应性，且各参数变化值与骨侵蚀变化情况密切相关。

关键词: 类风湿关节炎, 动态增强磁共振成像, 疗效, 骨侵蚀

Abstract: This paper investigated the changes in quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) before and after drug treatment for rheumatoid arthritis (RA) and the effects on bone erosion. 112 patients with RA were selected, and quantitative parameters[maximum enhancement (Emax), maximum relative enhancement (REmax), relative enhancement (RE), and slope of maximum enhancement (Slopemax)] were measured by DCE-MRI before and after drug treatment to compare quantitative DCE-MRI parameters and bone erosion scores before and after treatment in patients with and without response. The results showed that Emax, REmax, RE, and Slopemax in non-responders were higher than in responders before and after treatment, and the change values of Emax, REmax, RE, and Slopemax before and after treatment were lower than those of responders (P<0.05). The change values of Emax, REmax, RE, and Slopemax before and after treatment were positively correlated with drug treatment in RA patients(P<0.05). The area under the curve (AUC) of the combination of Emax, REmax, RE, and Slopemax before treatment to predict RA drug treatment responsiveness as non-response was 0.901 (95% CI:0.830-0.949). The bone erosion scores before and after treatment in non-responders were higher than in responders, and the change in bone erosion scores before and after treatment was lower than in responders (P<0.05). The values of Emax, REmax, RE, and Slopemax before and after treatment were positively correlated with the change in bone erosion score in RA patients (P<0.05). It can be seen that the quantitative parameters Emax, REmax, RE, and Slopemax of DCE-MRI before treatment can predict the responsiveness to RA drug treatment, and the change values of each parameter are closely related to the change of bone erosion.

Key words: rheumatoid arthritis, dynamic enhanced magnetic resonance imaging, efficacy, bone erosion

郑奕, 江迎春, 杨豪, 董战军, 陈艳, 李思强. 药物治疗前后RA患者DCE-MRI参数变化及对骨侵蚀情况的影响[J]. 影像科学与光化学, 2023, 41(1): 136-141.

ZHENG Yi, JIANG Yingchun, YANG Hao, DONG Zhanjun, CHEN Yan, LI Siqiang. Changes of DCE-MRI Parameters in RA Patients Before and After Drug Treatment and Its Effect on Bone Erosion[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 136-141.

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药物治疗前后RA患者DCE-MRI参数变化及对骨侵蚀情况的影响

Changes of DCE-MRI Parameters in RA Patients Before and After Drug Treatment and Its Effect on Bone Erosion

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