基于CoⅡ/ZnⅡ的四面体笼状配合物对ATP选择性荧光识别

doi:10.7517/j.issn.1674-0475.2014.01.098

影像科学与光化学 ›› 2014, Vol. 32 ›› Issue (1): 98-105.DOI: 10.7517/j.issn.1674-0475.2014.01.098

基于Co^Ⅱ/Zn^Ⅱ的四面体笼状配合物对ATP选择性荧光识别

焦扬, 严虞虞, 何成, 段春迎

大连理工大学精细化工国家重点实验室, 辽宁大连 116024

收稿日期:2013-12-03 修回日期:2013-12-17 出版日期:2014-01-15 发布日期:2014-01-15
通讯作者: 何成
基金资助:
国家自然科学基金项目（21171029）资助

Co^Ⅱ/Zn^Ⅱ Tetrahedron for Selectively Luminescent Recognition of ATP

JIAO Yang, YAN Yuyu, HE Cheng, DUAN Chunying

State key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, Liaoning, P. R. China

Received:2013-12-03 Revised:2013-12-17 Online:2014-01-15 Published:2014-01-15

摘要/Abstract

摘要：

金属有机笼状配合物因其独特的空间限域性、易组装、多功能化等特点，使其在选择性识别生物小分子时占有重要的优势。本文设计合成了具有高度对称性的有机配体H₃L₂，通过配位作用与过渡金属离子Zn^Ⅱ/Co^Ⅱ组装成金属有机笼状配合物Zn-L₂/Co-L₂。笼状配合物Zn-L₂和Co-L₂均为四面体构型，具有光学活性，为阳离子笼状配合物。以荧光为主要研究手段，对生物小分子核苷酸分子的识别作用进行研究，发现当与三磷酸腺苷ATP分子进行作用时，笼状配合物的荧光信号显著增强，实现了对ATP的选择性识别。

关键词: 核苷酸, 识别, 荧光, 笼状配合物

Abstract:

Because the unique spatial confinement, easy assembly and multi-functional features of cage-like metal-organic complexes, there is an important advantage for the selective recognition of small biological molecules. Here we reported a organic ligand L₂ which has a high degree of symmetry, and got two zinc/cobalt-based cage-like complexes Zn-L₂/Co-L₂ through complexation with transition metal ions Zn^Ⅱ / Co^Ⅱ. These two cage-like complexes Zn-L₂ and Co-L₂ are tetrahedron on geometry which have with optical activity. The tetrahedral complexes Zn-L₂/Co-L₂ are cationic cage-like complexes to studied the recognition for biological small molecules nucleotide. By means of fluorescence to study the interaction between nucleotide and tetrahedral complexes Zn-L₂/Co-L₂, we found that there were three aniline significantly enhanced fluorescence signal when only adenosine triphosphate molecule ATP was added. The tetrahedral complexes Zn-L₂/Co-L₂ are the selective recognition of ATP.

Key words: nucleotides, identification, fluorescence, cage-like complexes

焦扬, 严虞虞, 何成, 段春迎. 基于Co^Ⅱ/Zn^Ⅱ的四面体笼状配合物对ATP选择性荧光识别[J]. 影像科学与光化学, 2014, 32(1): 98-105.

JIAO Yang, YAN Yuyu, HE Cheng, DUAN Chunying. Co^Ⅱ/Zn^Ⅱ Tetrahedron for Selectively Luminescent Recognition of ATP[J]. Imaging Science and Photochemistry, 2014, 32(1): 98-105.

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基于Co^Ⅱ/Zn^Ⅱ的四面体笼状配合物对ATP选择性荧光识别

Co^Ⅱ/Zn^Ⅱ Tetrahedron for Selectively Luminescent Recognition of ATP

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基于CoⅡ/ZnⅡ的四面体笼状配合物对ATP选择性荧光识别

CoⅡ/ZnⅡ Tetrahedron for Selectively Luminescent Recognition of ATP

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基于Co^Ⅱ/Zn^Ⅱ的四面体笼状配合物对ATP选择性荧光识别

Co^Ⅱ/Zn^Ⅱ Tetrahedron for Selectively Luminescent Recognition of ATP