DCE-MRI检查五项参数与类风湿关节炎疾病活动度关系及临床价值

doi:10.7517/issn.1674-0475.210309

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (5): 721-726.DOI: 10.7517/issn.1674-0475.210309

DCE-MRI检查五项参数与类风湿关节炎疾病活动度关系及临床价值

郑婧¹, 任水明¹, 张凤翔², 高倩¹, 高婧¹, 杨永梅¹, 高凯乐²

1. 鄂尔多斯市中心医院风湿肾脏科, 内蒙古鄂尔多斯 017000;
2. 鄂尔多斯市中心医院影像科, 内蒙古鄂尔多斯 017000

收稿日期:2021-03-30 发布日期:2021-09-13
通讯作者: 任水明
基金资助:
鄂尔多斯市高端卫生健康人才培养项目

The Relationship between the Five Parameters of DCE-MRI and the Disease Activity of Rheumatoid Arthritis and Its Clinical Value

ZHENG Jing¹, REN Shuiming¹, ZHANG Fengxiang², GAO Qian¹, GAO Jing¹, YANG Yongmei¹, GAO Kaile²

1. Department of Rheumatology and Nephrology, Ordos Central Hospital, Ordos 017000, Inner Mongolia, P. R. China;
2. Department of Imaging, Ordos Central Hospital, Ordos 017000, Inner Mongolia, P. R. China

Received:2021-03-30 Published:2021-09-13

摘要/Abstract

摘要： 探究动态增强磁共振成像（DCE-MRI）检查五项参数与类风湿关节炎（RA）患者疾病活动度的相关性及联合预测近期预后的临床价值。选取105例RA患者作为研究对象，均根据治疗6个月后治疗反应情况分为预后良好组（80例）与预后不良组（25例）。结果发现，DCE-MRI检查参数RE、MRE、ME、Slope_max、AUC随疾病活动度增加呈升高趋势，与疾病活动度呈正相关（r=0.759、0.803、0.763、0.666、0.724，P<0.05），与近期预后显著相关；且DCE-MRI检查五项参数联合预测近期预后的AUC为0.937，95%CI为0.872～0.975，P<0.001，敏感度为80.00%，特异度为95.00%，显著优于单独预测。提示采用DCE-MRI检查五项参数可作为临床评估RA病情程度、预测近期预后的可靠手段，为临床提供科学循证依据。

关键词: 类风湿关节炎, 疾病活动度, 动态增强磁共振成像, 近期预后, 预测价值

Abstract: The correlation between the five parameters of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and the disease activity of patients with rheumatoid arthritis (RA) and the clinical value of joint prediction of short-term prognosis. A total of 105 RA patients were selected as the research objects. They were divided into a good prognosis group (80 cases) and a poor prognosis group (25 cases) according to the treatment response after 6 months of treatment. The results showed that RE, MRE, ME, Slope_max and AUC in DCE-MRI showed an increasing trend with the increase of disease activity, and were positively correlated with disease activity (r=0.759, 0.803, 0.763, 0.666, 0.724, P<0.05). Significantly related to the short-term prognosis. The five parameters of DCE-MRI examination combined predict the short-term prognosis AUC of 0.937, 95%CI of 0.872-0.975, P<0.001, sensitivity of 80.00%, specificity of 95.00%, significantly better than individual forecast.It is suggested that the five parameters of DCE-MRI examination can be used as a reliable method to clinically evaluate the severity of RA and predict the short-term prognosis, and provide a scientific evidence-based basis for the clinic.

Key words: rheumatoid arthritis, disease activity, dynamic contrast enhanced magnetic resonance imaging, short-term prognosis, predictive value

郑婧, 任水明, 张凤翔, 高倩, 高婧, 杨永梅, 高凯乐. DCE-MRI检查五项参数与类风湿关节炎疾病活动度关系及临床价值[J]. 影像科学与光化学, 2021, 39(5): 721-726.

ZHENG Jing, REN Shuiming, ZHANG Fengxiang, GAO Qian, GAO Jing, YANG Yongmei, GAO Kaile. The Relationship between the Five Parameters of DCE-MRI and the Disease Activity of Rheumatoid Arthritis and Its Clinical Value[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 721-726.

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DCE-MRI检查五项参数与类风湿关节炎疾病活动度关系及临床价值

The Relationship between the Five Parameters of DCE-MRI and the Disease Activity of Rheumatoid Arthritis and Its Clinical Value

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