核素显像技术与急性心梗后心室重构患者免疫炎性损伤关系研究

doi:10.7517/issn.1674-0475.210504

摘要/Abstract

摘要： 本研究探讨了核素显像技术在急性心肌梗死后心室重构中的评价作用及与免疫炎性损伤的关系。选取急性心肌梗死患者90例，其中左心室重构患者43例，无左心室重构患者47例。左心室重构患者左心室舒张末期容积指数（LVEDVI）、左心室收缩末期容积指数（LVESVI）、室壁增厚异常总积分（STS）、心肌总灌注不足（TPD）、存活心肌和瘢痕心肌、内皮素-1（ET-1）、超敏C反应蛋白（hs-CRP）和肿瘤坏死因子α（TNF-α）明显高于无左心室重构患者（P<0.05）；左心室重构患者血清一氧化氮（NO）、左心室射血分数（LVEF）明显低于无左心室重构患者（P<0.05）；STS与ET-1、hs-CRP呈正相关（r=0.333和0.429，P<0.05）；STS、ET-1、hs-CRP是急性心肌梗死后心室重构的影响因素（P<0.05）。核素显像技术在急性心肌梗死后心室重构评价中有一定价值，与血管内皮损伤和炎性因子有关。

关键词: 核素显像技术, 急性心肌梗死, 心室重构, 血管内皮损伤, 炎性因子

Abstract: The purpose of this study was to investigate the role of radionuclide imaging in evaluating ventricular remodeling after acute myocardial infarction and its relationship with immune inflammatory injury. 90 patients with acute myocardial infarction were selected, including 43 patients with left ventricular remodeling and 47 patients without left ventricular remodeling. The left ventricular remodeling in patients with left ventricular end-diastolic volume index (LVEDVI), left ventricular end systolic volume index (LVESVI), summed thickening score (STS), total perfusion defect (TPD), survival myocardium, scar myocardium, endothelin-1 (ET-1), high sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α) were significantly higher than those without left ventricular remodeling (P<0.05). The level of serum nitric oxide (NO) and left ventricular ejection fraction (LVEF) in patients with left ventricular remodeling was significantly lower than that in patients without left ventricular remodeling (P<0.05). STS was positively correlated with ET-1 and hs-CRP (r=0.333 and 0.429, P<0.05); STS, ET-1 and hs-CRP were the influencing factors of ventricular remodeling after acute myocardial infarction (P<0.05). Radionuclide imaging has a certain value in the evaluation of ventricular remodeling after acute myocardial infarction, which is related to vascular endothelial injury and inflammatory factors.

Key words: radionuclide imaging technology, acute myocardial infarction, ventricular remodeling, vascular endothelial injury, inflammatory factors

杨立慧, 丁伟平. 核素显像技术与急性心梗后心室重构患者免疫炎性损伤关系研究[J]. 影像科学与光化学, 2021, 39(6): 840-844.

YANG Lihui, DING Weiping. The Relationship between Nuclide Imaging and Immunoinflammatory Injury in Patients with Ventricular Reconstruction after Acute Myocardial Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(6): 840-844.

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