脑部磁共振结合静息态fMRI方法在卒中患者认知障碍中的应用

doi:10.7517/issn.1674-0475.210719

摘要/Abstract

摘要： 本研究主要探讨脑部磁共振结合静息态fMRI方法在卒中患者认知障碍中的应用。本研究将符合卒中认知障碍患者25例设为患者组，将25例健康者设为对照组。采用脑部静息态核磁共振对实验者进行扫描，以脑部双侧海马为种子点进行功能连接分析，并通过软件分析两组实验者静息态双侧海马差异。结果发现，与对照组相比，患者组右侧海马与左右侧额中回、左侧额下回等的连接减少；右侧海马与左侧颞上中回、双侧丘脑的连接增加；左侧海马与左侧颞额中回、右侧颞额上回、右侧额下回的连接减少；左侧海马与右侧顶下回连接增加。总之，本研究发现卒中患者海马脑区与颞叶皮层、额叶皮层之间的连接减少，可能是由卒中患者脑损害导致。

关键词: 磁共振成像, 静息态, 卒中, 认知障碍, 功能连接

Abstract: This study explored the application of brain magnetic resonance combined with resting state fMRI in the cognitive impairment of stroke patients. In this study, 25 patients with cognitive impairment who met stroke were set as the patient group, and 25 healthy patients were set as the control group. The resting state MRI of the brain was used to scan the experimenters, and the bilateral hippocampus of the brain were used as seed points for functional connectivity analysis, and the difference between the two groups of experimenters' resting hippocampus was analyzed through the software. The results showed that compared with the control group, the connection between the right hippocampus and the left and right middle frontal gyrus and the left inferior frontal gyrus decreased in the patient group; the connection between the superior temporal gyrus of the right hippocampus and the left superior middle gyrus and bilateral thalamus increased; the connection between the left middle frontal gyrus and the left middle temporal frontal gyrus, the right superior frontal gyrus, and the right lower frontal gyrus decreased; the connection between the left hippocampus and the right parietal inferior gyrus increased. In summary, this study found that the connections between the hippocampus and the temporal cortex and frontal cortex of stroke patients are reduced, which may be caused by brain damage in stroke patients.

Key words: magnetic resonance imaging (MRI), resting state, stroke, cognitive impairment, functional connectivity

汝宁, 姚明仁, 白新苹, 王幼萌. 脑部磁共振结合静息态fMRI方法在卒中患者认知障碍中的应用[J]. 影像科学与光化学, 2022, 40(1): 188-191.

RU Ning, YAO Mingren, BAI Xinping, WANG Youmeng. Application of Brain Magnetic Resonance Combined with Resting State fMRI in the Cognitive Impairment of Stroke Patients[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(1): 188-191.

参考文献

[1] Rafii M S, Hillis A E. Compendium of cerebrovascular diseases[J]. International Review of Psychiatry, 2006, 18(5):395-407.
[2] Huang K Y, Liang F C, Yang X L, et al. Long term exposure to ambient fine particulate matter and incidence of stroke:Prospective cohort study from the China-PAR project[J]. British Medical Journal, 2019, 367:l6720.
[3] Hamblin M R. Photobiomodulation for traumatic brain injury and stroke[J]. Journal of Neuroscience Research, 2018, 96(4):731-743.
[4] Santos Armentia E, Martín Noguerol T, Suárez Vega V. Advanced magnetic resonance imaging techniques for tumors of the head and neck[J]. Radiología Medica, 2019, 61(3):191-203.
[5] Peters L, De Smedt B. Arithmetic in the developing brain:A review of brain imaging studies[J]. Developmental Cognitive Neuroscience, 2018, 30:265-279.
[6] Schwarz L, Kreifelts B, Wildgruber D, et al. Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting[J]. PLoS One, 2019, 14(4):e0214997.
[7] Seitzman B A, Snyder A Z, Leuthardt E C, et al. The state of resting state networks[J]. Topics in Magnetic Resonance Imaging, 2019, 28(4):189-196.
[8] Lee M H, Smyser C D, Shimony J S. Resting-state fMRI:A review of methods and clinical applications[J]. American Journal of Neuroradiology, 2013, 34(10):1866-1872.
[9] Eyler L T, Elman J A, Hatton S N, et al. Resting state abnormalities of the default mode network in mild cognitive impairment:A systematic review and Meta-analysis[J]. Journal of Alzheimer's Disease, 2019, 70(1):107-120.
[10] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组. 中国急性缺血性脑卒中诊治指南2010[J]. 中华神经科杂志, 2010, 43(2):146-156.
[11] Beez T, Steiger H J, Etminan N. Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis-a systematic review and meta-analysis[J]. BMC Neurology, 2017, 17(1):1-2.
[12] Sun M S, Jin H, Sun X, et al. Free radical damage in ischemia-reperfusion injury:An obstacle in acute ischemic stroke after revascularization therapy[J]. Oxidative Medicine And Cellular Longevity, 2018, 2018:3804979.
[13] Wu T, Zang Y F, Wang L, et al. Normal aging decreases regional homogeneity of the motor areas in the resting state[J]. Neuroscience Letters, 2007, 423(3):189-193.
[14] Khanna A, Pascual-Leone A, Michel C M, et al. Microstates in resting-state EEG:Current status and future directions[J]. Neuroscience & Biobehavioral Reviews, 2015, 49:105-113.
[15] Smitha K A, Akhil Raja K, Arun K M, et al. Resting state fMRI:A review on methods in resting state connectivity analysis and resting state networks[J]. The Neuroradiology Journal, 2017, 30(4):305-317.
[16] Oliva A, Fernández-Ruiz A, Leroy F, et al. Hippocampal CA2 sharp-wave ripples reactivate and promote social memory[J]. Nature, 2020, 587(7833):264-269.
[17] Ólafsdóttir H F, Bush D, Barry C. The role of hippocampal replay in memory and planning[J]. Current Biology, 2018, 28(1):R37-R50.
[18] Voss J L, Bridge D J, Cohen N J, et al. A closer look at the Hippocampus and memory[J]. Trends in Cognitive Sciences, 2017, 21(8):577-588.
[19] Wang K, Jiang T, Yu C, et al. Spontaneous activity associated with primary visual cortex:A resting-state FMRI study[J]. Cerebral Cortex, 2008, 18(3):697-704.
[20] 柴宁, 王岚, 王学义. 轻度认知损害功能核磁共振研究的进展[J]. 中华行为医学与脑科学杂志, 2013, 4:383-384.
[21] Liao Y Y, Tseng H Y, Lin Y J, et al. Using virtual reality-based training to improve cognitive function, instrumental activities of daily living and neural efficiency in older adults with mild cognitive impairment[J]. European Journal of Physical and Rehabilitation Medicine, 2020, 56(1):47-57.