The Value of Multi-parameter MRI in the Differential Diagnosis of Uterine Sarcoma and Benign Uterine Fibroids and the Relationship with the Malignant Degree of Tumor Cells

doi:10.7517/issn.1674-0475.200613

Abstract

Abstract: In this research, 103 uterine sarcoma (US) patients were selected as the observation group, and 103 patients with benign uterine fibroids were selected as the control group. The value of MRI multi-parameters in the differential diagnosis of US and benign uterine fibroids were explored, as well as the relationship between the MRI parameters and the malignancy of tumor cells. The time to peak (TTP) and apparent diffusion coefficient (ADC) of the observation group were lower than those of the control group. TTP and ADC showed a downward trend with the increase of clinical stage, while the relative expression of TopoⅡα, AgNOR, PDGFα, and Matriptase mRNA showed an increasing trend with the increase of clinical stage. TP, ADC were negatively correlated with TopoⅡα, AgNOR, PDGFα and Matriptase mRNA relative expression. And the combined AUC value of TTP and ADC was the largest in differential diagnosis of US and benign uterine fibroids. These results indicated that there were significant differences in MRI parameters between US and benign uterine fibroids. TTP and ADC values are directly related to the activities of proliferation molecules and invasion molecules, which can provide data support for clinical differential diagnosis.

Key words: MRI, uterine sarcoma, uterine fibroids, tumor cells, matriptase, TopoⅡα, proliferation molecules

BU Dao, HAN Qianqian. The Value of Multi-parameter MRI in the Differential Diagnosis of Uterine Sarcoma and Benign Uterine Fibroids and the Relationship with the Malignant Degree of Tumor Cells[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(1): 81-86.

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