Study on the Efficacy of Colonoscopy Combined with CEA and CA242 in Identifying Colo-rectal Polyps and Cancer

doi:10.7517/issn.1674-0475.200911

Abstract

Abstract: The purpose of this study was to investigate the efficacy of colonoscopy in evaluating the diameter and number of lesions combined with carcinoembryonic antigen (CEA) and carbohydrate antigen 242 (CA242) in the identification of colo-rectal polyps and cancer. From January 2018 to January 2020, 212 patients with colo-rectal cancer were selected as the observation group, and 100 patients with colo-rectal polyps during the same period were selected as the control group. The clinical data, the diameter of the lesion, the number of lesions, the expression of CEA and CA242 were compared between the two groups. It was found that after controlling for factors such as age and family history, lesion diameter, number of lesions, adenomatous lesions, CEA and CA242 expression were still significantly correlated with colo-rectal cancer (P<0.05). The AUC of the combined differential diagnosis of colo-rectal cancer was 0.870, which was greater than any single index (P<0.05). Therefore, the diameter, number of lesions and pathological types of colonoscopy are related to the expression levels of CEA and CA242, which are related factors in the incidence of colo-rectal cancer. The combined detection of various indicators is expected to provide a new method for the diagnosis and differentiation of colo-rectal polyps and cancer.

Key words: colonoscopy, lesion diameter, number of lesions, CEA, CA242, colon polyp, colo-rectal cancer

LUO Xiong, XIA Yuxin, SUN Xiaomei, LI Mingyue, WANG Kehan, WU Cheng. Study on the Efficacy of Colonoscopy Combined with CEA and CA242 in Identifying Colo-rectal Polyps and Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(2): 280-285.

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