Abstract: The purpose of this study is to explore the correlation between shear wave elastography (SWE) technical parameters and contrast-enhanced ultrasound (CEUS) parameters of benign and malignant thyroid nodules, and the value of combined diagnosis of benign and malignant thyroid nodules by SWE and CEUS. Fifty-one patients with malignant thyroid nodules in our hospital were selected as the malignant group, and 63 patients with benign thyroid nodules were selected as the benign group. All of them underwent SWE and CEUS examinations. The diagnostic value was analyzed. The results of the study found that E_min, E_mean, E_max and Peak was negatively correlated and positively correlated with Tp (P<0.05); the AUC value of the combined diagnosis of malignant thyroid nodules by SWE and CEUS was 0.952, which was greater than any single index diagnosis (P<0.05); E_min, E_mean, E_max, Tp, MTT is positively correlated with clinical stage, nodule size, and calcification, and negatively correlated with the degree of differentiation. Peak is negatively correlated with clinical stage, nodule size, and calcification, and positively correlated with the degree of differentiation (P<0.05). These results can be It is confirmed that the combination of SWE technology and CEUS in the diagnosis of thyroid benign and malignant nodules is of high value, and plays an important role in guiding clinical development of treatment plans.

Key words: thyroid, nodules, shear wave elastography, peak intensity, contrast-enhanced ultrasound, mean transit time of contrast agent