The Value of WBS Combined with SPECT/CT Tomographic Fusion in the Diagnosis of Solitary Bone Metastases in Extremities of Lung Cancer

doi:10.7517/issn.1674-0475.210520

Abstract

Abstract: The purpose of this study was to investigate the value of whole body bone scan (WBS) combined with single photon emission computed tomography (SPECT)/CT fusion in the diagnosis of single bone metastasis in lung cancer limbs. A retrospective study was conducted, 140 cases of lung cancer patients were selected and given WBS, SPECT/CT tomographic fusion examination. The proportion of adenocarcinoma in the bone metastasis group was significantly higher than that in benign bone lesions (P<0.05). The proportion of bone destruction, density change of bone marrow cavity and bone cortical defect in the bone metastasis group were significantly higher than that in benign bone lesions (P<0.05). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of WBS combined with SPECT/CT in diagnosis of bone metastasis were significantly higher than those of WBS (P<0.05). WBS combined with SPECT/CT fusion has a good value in the diagnosis of single bone metastasis in extremities of lung cance.

Key words: whole body bone scan, single photon emission computed tomography, computer tomo-graphy (CT), lung cancer, bone metastasis, diagnostic value

WU Fengping, WU Jing. The Value of WBS Combined with SPECT/CT Tomographic Fusion in the Diagnosis of Solitary Bone Metastases in Extremities of Lung Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(6): 808-812.

References

[1] 麦家杰, 张金山, 李志钊, 等. 血清碱性磷酸酶、Ca²⁺水平在肺癌早期骨转移诊断中的临床意义[J]. 中国中西医结合影像学杂志, 2019, 17(5):484-488.
[2] Zhang L Q, He Q, Zhou T, et al. Accurate characterization of 99mTc-MDP uptake in extraosseous neoplasm mimicking bone metastasis on whole-body bone scan:Contribution of SPECT/CT[J]. BMC Medical Imaging, 2019, 19(1):44.
[3] Papageorgiou I, Dvorak J, Cosma I, et al. Whole-body MRI:A powerful alternative to bone scan for bone marrow staging without radiation and gadolinium enhancer[J]. Clinical and Translational Oncology, 2020, 22(8):1321-1328.
[4] 孙斌, 刘举珍, 张飞飞. SPECT/CT断层融合显像联合血清CEA、CYFRA21-1在诊断非小细胞肺癌骨转移中的应用[J]. 国际放射医学核医学杂志, 2018, 42(3):212-217.
[5] Qiu L, Tan H, Yin H Y, et al. Comparison of post-therapeutic sequential ¹³¹I whole-body scans in the detection of metastatic thyroid cancer[J]. The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2020, 64(3):313-320.
[6] 曹仲年, 耿建华, 魏正茂, 等. 小细胞肺癌诊断因素与全身骨显像骨转移之间的关系[J]. 中国医学装备, 2019, 16(6):73-75.
[7] Karamzade-Ziarati N, Manafi-Farid R, Ataeinia B, et al. Molecular imaging of bone metastases using tumor-targeted tracers[J]. The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2019, 63(2):136-149.
[8] 尚大雷, 陈书成. SPECT骨显像联合血清CYFRA21-1、CEA诊断NSCLC患者骨转移的临床价值分析[J]. 中国CT和MRI杂志, 2020, 18(5):139-142.
[9] Yamane T, Kondo A, Takahashi M, et al. Ultrafast bone scintigraphy scan for detecting bone metastasis using a CZT whole-body gamma camera[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2019, 46(8):1672-1677.
[10] Iwano S, Ito S, Kamiya S, et al. Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer[J]. Nagoya Journal of Medical Science, 2020, 82(2):205-215.
[11] Chambard L, Girard N, Ollier E, et al. Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers[J]. Bone, 2018, 108:202-209.
[12] 汪峰, 聂慧, 张汝森, 等. 肺癌患者行全身骨扫描后再行胸部SPECT/CT的获益分析[J]. 中国肿瘤临床, 2020, 47(18):929-934.
[13] Xu X X, Zhu H, Liu F, et al. Imaging brain metastasis patients with ¹⁸F-(2S, 4R)-4-fluoroglutamine[J]. Clinical Nuclear Medicine, 2018, 43(11):e392-e399.
[14] Papandrianos N, Papageorgiou E I, Anagnostis A. Development of Convolutional Neural Networks to identify bone metastasis for prostate cancer patients in bone scintigraphy[J]. Annals of Nuclear Medicine, 2020, 34(11):824-832.
[15] 吴一田. PET/CT及SPECT、SPECT/CT辐射剂量与图像质量的模型研究[D]. 北京:北京协和医学院, 2018.
[16] 崔泽升, 王少纯. MRI联合SPECT/CT在脊柱病变鉴别诊断中的价值分析[J]. 中国CT和MRI杂志, 2020, 18(5):133-135, 138.
[17] 李占银, 阿尖措, 苏桂芳. SPECT/CT结合三相骨显像诊断假体周围感染的价值分析[J]. 中国CT和MRI杂志, 2019, 17(12):139-142.