Abstract: This paper explored the value of real-time contrast-enhanced ultrasonography (rTCEUS) in evaluating renal blood perfusion after percutaneous transluminal renal angioplasty and PTRAS in patients with severe atherosclerotic renal artery stenosis. 31 patients with severe atherosclerotic renal artery stenosis (ARAS 70%) who received PTRAS were selected as the research objects, and all patients underwent color-coded duplex ultrasound (CCDS) and rTCEUS, respectively and compared the time-intensity curve (TIC) parameters of rTCEUS contrast enhancement in patients before and after PTRAS. The morphological changes of TIC before and after PTRAS were recorded, and the correlation between the parameters before and after PTRAS and the estimated glomerular filtration rate (EGFR) was calculated. The peak intensity (PI) and rising slope (S) of the curve after PTRAS were significantly higher than those before PTRAS (P<0.05), while the peak time (TTP) and mean transit time (MTT) were significantly lower than those before PTRAS (P<0.05). There had no significant differences in the area under the curve (AUC), AUC-influx (AUC-WI) and AUC-clearance (AUC-WO) between pre-PTRAS and post-PTRAS (P>0.05). There was no correlation between ΔEGFR and ΔTTP, ΔMTT, ΔS, ΔAUC, ΔAUC-WI and ΔAUC-WO (all P>0.05) except ΔPI with positive correlation (P<0.05). Parameters obtained by rTCEUS have a great value in evaluating the changes of renal blood flow in patients with severe renal artery stenosis after PTRAS.

Key words: renal artery stenosis, percutaneous transluminal angioplasty and stenting, doppler ultrasound, contrast-enhanced, blood perfusion