Abstract: This study investigated the value of conventional transvaginal ultrasound and shear wave elastography (SWE) combined with serum carcinoembryonic antigen (CEA) in the diagnosis of endometrial cancer. 152 patients with endometrial lesions were selected, all patients underwent pathological examination, conventional transvaginal ultrasound and SWE examination, and the levels of serum CEA were detected. The patients were divided into malignant group and benign group according to the results of pathological examination. The conventional transvaginal ultrasound indicators (endometrial thickness, RI, PI), SWE indicators (Emean, Esd, Emax), and serum CEA levels of the two groups were compared. The value of above indicators alone and combined in the diagnosis of endometrial cancer were analyzed by ROC curve. The results showed that 89 patients were diagnosed with 270endometrial cancer (malignant group), and 63 patients were diagnosed with benign endometrial lesions (benign group). The endometrial thickness of the malignant group was greater than that in the benign group, the RI and PI were lower than those in the benign group, the levels of Emean, Esd, Emax, and serum CEA were higher than those in the benign group (P<0.05). Endometrial thickness, Emean, Esd, Emax, CEA, RI, and PI were risk factors for endometrial cancer (P<0.05). The AUC of endometrial thickness, RI, PI, Emean, Esd, Emax, and CEA alone and combined in the diagnosis of endometrial cancer were 0.765, 0.788, 0.834, 0.812, 0.768, 0.790, 0.811, and 0.970, respectively. The conventional transvaginal ultrasound and SWE combined with serum CEA have high value in the diagnosis of endometrial cancer.

Key words: endometrial cancer, conventional transvaginal ultrasound, shear wave elastography, carcinoembryonic antigen, diagnostic value