Evaluation of Cerebral Blood Flow in Chronic Cerebral Infarction by 3D-ASL and Its Correlation with Cognitive Function

doi:10.7517/issn.1674-0475.220708

Abstract

Abstract: In this study, 3D arterial spin labeling perfusion imaging (3D-ASL) was used to evaluate cerebral blood flow (CBF) in chronic cerebral infarction and its correlation with cognitive function. 64 patients with chronic cerebral infarction were selected as the chronic group, 60 patients with acute cerebral infarction were selected as the acute group, and 50 patients with subacute cerebral infarction were selected as the subacute group. The CBF and relative cerebral blood flow (rCBF) of the affected side and the healthy side were compared among the three groups. The CBF and rCBF of the affected side in the chronic phase group were significantly lower than those in the acute phase group and the acute phase group (P<0.05). The Mini Mental State Scale (MMSE) and Montreal Cognitive Assessment Scale (MoCA) and Fugl-Meyer score of patients in chronic stage group were significantly lower than those in subacute stage group and acute stage group (P<0.05). Ipsilateral CBF and rCBF were positively correlated with MMSE score and MoCA score (P<0.05). Logistic regression analysis showed that age, diabetes, ipsilateral CBF and rCBF were the influencing factors of cognitive dysfunction in patients with chronic cerebral infarction (P<0.05). CBF is correlated with cognitive function in patients with chronic cerebral infarction. 3D-ASL assessment of CBF is helpful to understand the cognitive function impairment in patients with chronic cerebral infarction.

Key words: 3D arterial spin labeling perfusion imaging, chronic phase, cerebral infarction, cerebral blood flow

MENG Qingning, SHI Gang, WANG Runqiang. Evaluation of Cerebral Blood Flow in Chronic Cerebral Infarction by 3D-ASL and Its Correlation with Cognitive Function[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1433-1437.

References

[1] 郭瑜, 夏爽, 马国林. 动脉自旋标记成像技术在脑灌注、侧支循环评价中的应用进展[J]. 中华医学杂志, 2021, 101(23):1827-1830.
[2] 李玉洁, 林蒙. 动脉自旋标记灌注成像技术在颈体部的临床应用进展[J]. 放射学实践, 2020, 35(5):673-677.
[3] 陈艳, 胡发云, 吴波. 《中国脑血管疾病分类2015》解读[J].中国现代神经疾病杂志, 2017, 17(12):865-868.
[4] 周小炫, 谢敏, 陶静, 等. 简易智能精神状态检查量表的研究和应用[J]. 中国康复医学杂志, 2016, 31(6):694-696, 706.
[5] 万小勇, 杨登元. 蒙特利尔认知评估与MMSE量表在老年认知障碍筛查中的应用[J]. 成都医学院学报, 2012, 7(4):648-650.
[6] 张冉, 马梦尧, 苏欣宇, 等. 大鼠脑缺血/再灌注过程中血流量和脑组织含水量的变化趋势[J]. 中国应用生理学杂志, 2020, 36(6):586-589, 686.
[7] 叶靓, 商德胜, 张劼, 等. 卒中后失语患者语言相关脑区的脑血流灌注影像研究[J]. 中华神经科杂志, 2020, 53(9):664-671.
[8] 孔祥泉, 刘定西, 江利, 等. 脑梗死在扩散加权像上信号强度及表面扩散系数变化的时间过程[J]. 中华放射学杂志, 2000, 34(5):325-329.
[9] 黄力, 王秀河, 刘斯润, 等. MR表观扩散系数图在脑梗死演变诊断中的价值[J]. 中华放射学杂志, 2004, 38(2):139-143.
[10] 罗玲, 黄华品. 不同部位脑梗死患者血脂水平及其与认知关系的分析[J]. 福建医药杂志, 2016, 38(4):68-70.
[11] 吴雅蔚, 叶靖, 王守安, 等. 基于三维动脉自旋标记灌注成像探讨体素内不相干运动成像对急性期脑梗死的应用价值[J]. 中国医学计算机成像杂志, 2020, 26(3):201-205.
[12] 杨婷, 顾太富, 张冉, 等. 三维伪连续式动脉自旋标记及体素内不相干运动成像评估脑胶质瘤IDH1基因分型[J]. 中国医学影像技术, 2021, 37(7):979-983.
[13] 黄晓琪, 陈玲, 林阳洋, 等. 三维动脉自旋标记在急性脑梗死功能恢复评估中的应用[J]. 实用放射学杂志, 2020, 36(1):9-13.
[14] 李晶龙, 刘筠, 邹繁婕, 等. 双反转时间动脉自旋标记成像评估急性缺血性脑卒中梗死后高灌注的临床价值[J]. 实用放射学杂志, 2020, 36(2):184-188, 193.
[15] 史素敏, 李海梅, 张志勇, 等. 基于多延迟动脉自旋标记对单侧大脑中动脉重度狭窄/闭塞患者软脑膜支及深穿支脑灌注改变分析[J]. 中华医学杂志, 2021, 101(23):1784-1790.