MR弥散张量成像及弥散张量纤维束示踪成像在不同级别脑胶质瘤诊断中的应用

doi:10.7517/issn.1674-0475.210105

摘要/Abstract

摘要： 本文探讨不同级别脑胶质瘤诊断中应用MR弥散张量成像（DTI）及弥散张量纤维束示踪成像（DTT）的价值。选取脑胶质瘤患者84例，比较低级别和高级别脑胶质瘤DTI、DTT参数差异。实验结果显示：高级别瘤周白质纤维束破坏比例明显高于低级别（P<0.05）；高级别病灶实质区部分各向异性（FA）值明显高于低级别脑胶质瘤（P<0.05），而表观扩散系数（ADC）值明显低于低级别（P<0.05）；高级别瘤周水肿区纤维密度指数（FDi）值明显低于低级别（P<0.05）；瘤周白质纤维束破坏，病灶实质区FA值和ADC值，瘤周水肿区FDi值鉴别诊断高级别脑胶质瘤的ROC曲线下面积分别为0.857、0.877、0.965和0.828（P<0.05）。研究证实：同级别脑胶质瘤中，DTI及DTT参数有所差异，在鉴别诊断中有一定应用价值。

关键词: MR弥散张量成像, 弥散张量纤维束示踪成像, 脑胶质瘤, 诊断价值

Abstract: The purpose of this study was to investigate the value of MR diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in the diagnosis of glioma of different grade. 84 patients with glioma were selected, the DTI and DTT parameters of low grade and high grade gliomas were compared. The experimental results showed that the damage rate of peritumor white matter fiber bundle in high-grade was significantly higher than that in low-grade (P<0.05). The fractional anisotropy (FA) value of focal parenchymal area in high-grade was significantly higher than that of the low-grade (P<0.05), and the apparent diffusion coefficient (ADC) value was significantly lower than that of the low-grade (P<0.05). The value of fiber density index (FDi) in the peritumor edema area of high-grade was (0.53±0.08), which was significantly lower than that of low-grade (P<0.05). The area under ROC curve of peritumor white matter fiber bundle destruction, FA value and ADC value of lesion parenchyma area, and FDi value of peritumor edema area in differential diagnosis of high grade were 0.857, 0.877, 0.965 and 0.828, respectively (P<0.05). This study confirmed that:DTI and DTT parameters are different in different grades of glioma, which has certain application value in differential diagnosis.

Key words: MR diffusion tensor imaging, diffusion tensor tractography, brain glioma, diagnostic value

万正国, 贾雯, 孙源源, 吕晓清, 孟凯龙. MR弥散张量成像及弥散张量纤维束示踪成像在不同级别脑胶质瘤诊断中的应用[J]. 影像科学与光化学, 2021, 39(5): 663-666.

WAN Zhengguo, JIA Wen, SUN Yuanyuan, LV Xiaoqing, MENG Kailong. The Application of DTI and DTT in the Diagnosis of Different Grades of Gliomas[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 663-666.

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