超声靶向微泡破坏技术在心肌梗死中的应用研究进展

doi:10.7517/issn.1674-0475.220404

摘要/Abstract

摘要： 超声靶向微泡破坏（UTMD）技术是一种新型物理性质靶向基因递送系统，该技术是心肌梗死治疗的热点研究领域。本综述介绍了微泡的结构和功能及其发展历程，讨论了UTMD技术的应用原理，论述了UTMD技术在心肌梗死中的应用现状。从促进血管生成、促进移植细胞归巢、促进梗死心肌再生、减少心肌细胞凋亡、抑制氧化应激和改善心肌微环境等角度分析了UTMD技术治疗心肌梗死的可能机制。在此基础上，探讨了UTMD技术的优势与不足。本综述将对UTMD技术的研究现状进行总结，从而为该技术的后期研发提供理论支持。

关键词: 超声, 微泡, 超声靶向微泡破坏技术, 心肌梗死, 心肌缺血再灌注

Abstract: Ultrasound-targeted microbubble destruction (UTMD) technology is a novel physical property-targeted gene delivery system, which is a hot research field in the treatment of myocardial infarction. This review introduced the structure, function and development of microbubbles, and discussed the application principle of UTMD technology and the application status of UTMD technology in myocardial infarction. The possible mechanisms of UTMD in the treatment of myocardial infarction were analyzed from the perspectives of promoting angiogenesis, promoting homing of transplanted cells, promoting the regeneration of infarcted myocardium, reducing myocardial cell apoptosis, inhibiting oxidative stress and improving myocardial microenvironment. On this basis, the advantages and disadvantages of UTMD technology were discussed. This review will summarize the research status of UTMD technology, so as to provide theoretical support for the later research and development of this technology.

Key words: ultrasound, microbubble, ultrasound-targeted microbubble destruction technology, myocardial infarction, myocardial ischemia-reperfusion

陆相翔, 刘燕, 黄照河. 超声靶向微泡破坏技术在心肌梗死中的应用研究进展[J]. 影像科学与光化学, 2022, 40(5): 1010-1014.

LU Xiangxiang, LIU Yan, HUANG Zhaohe. Research Progress in the Application of Ultrasound-targeted Microbubble Destruction Technology in Myocardial Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1010-1014.

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