CT灌注成像对肝癌TACE术后早期反应预测价值的Meta分析

doi:10.7517/issn.1674-0475.230608

影像科学与光化学 ›› 2023, Vol. 41 ›› Issue (5): 260-269.DOI: 10.7517/issn.1674-0475.230608

CT灌注成像对肝癌TACE术后早期反应预测价值的Meta分析

毕孝杨¹, 邱瑞珍¹, 杨福军¹, 范潇燕¹, 帅师¹, 唐艳隆²

1. 大理大学临床医学院, 云南大理 671000;
2. 大理大学第一附属医院放射科, 云南大理 671000

收稿日期:2023-06-30 出版日期:2023-09-23 发布日期:2023-10-28
通讯作者: 唐艳隆
基金资助:
云南省教育厅科学研究基金项目(2023Y0987)、大理大学临床医学院学科队伍建设重点项目(DFYZD2022-04)、云南省省校合作地方高校联合专项项目(202001BA070001-149)和云南省卫生健康委员会医学后备人才培养计划(H-2018010)资助

The Value of Preoperative CT Perfusion Imaging in Predicting the Early Response of Hepatocellular Carcinoma after TACE: A Meta Analysis

BI Xiaoyang¹, QIU Ruizhen¹, YANG Fujun¹, FAN Xiaoyan¹, SHUAI Shi¹, TANG Yanlong²

1. College of Clinical Medicine, Dali University, Dali 671000, Yunnan, P.R. China;
2. Department of Radiology, the First Affiliated Hospital of Dali University, Dali 671000, Yunnan, P.R. China

Received:2023-06-30 Online:2023-09-23 Published:2023-10-28

摘要/Abstract

摘要： 系统评价术前计算机体层灌注成像(CTPI)参数对肝癌经肝动脉化疗栓塞(TACE)术后早期反应的预测价值。通过计算机检索中国知网、万方、维普、PubMed、Medline、Web of Science、Embase数据库中有关CT灌注成像和TACE预后关系的研究,使用RevMan 5.4软件进行Meta分析,效应量为均数差(MD),各效应量以95%置信区间(CI)表示。共纳入7篇文献,包括433名患者,共475个肿瘤病灶。Meta分析结果显示,肝癌TACE术后有反应组和无反应组肝动脉灌注量(ALP)差异有统计学意义(MD=16.84,95%CI 2.06～31.62,P＜0.05),有反应组ALP明显高于无反应组,最佳截断值范围为9.885～22.175 mL/(100 mL·min);肝癌TACE术后早期有反应组和无反应组门静脉灌注量(PVP)、肝动脉灌注指数(HPI)、血流量(BF)、血容量(BV)、平均通过时间(MTT)、达峰时间(TTP)差异无统计学意义(P>0.05)。术前高ALP可以预测肝癌TACE术后早期有效,但是ALP更确切的截断值需要进一步研究。

关键词: CT灌注成像, 肝癌, TACE术后, Meta分析

Abstract: To systematically evaluate the predictive value of preoperative computed tomography perfusion imaging (CTPI) parameters in early response to transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). The relationship between CT perfusion imaging and TACE prognosis was searched in China knowledge Network, Wanfang, VIP, PubMed, Medline, Web of Science and Embase databases by computer. Meta analysis was carried out by using RevMan 5.4 software. The mean difference (MD) was used, and each effect was expressed by 95% confidence interval (CI). A total of 7 articles were included, including 433 patients with a total of 475 tumor lesions. Meta analysis showed that there was significant difference in arterial liver perfusion (ALP) between the reactive group and the non-responsive group after TACE (MD=16.84,95%CI 2.06~31.62, P<0.05). The ALP of reactive group was significantly higher than that of non-responsive group, and the 260best cut-off value range was 9.885~22.175 mL/ (100 mL ·min). There was no significant difference in portal venous liver perfusion (PVP), hepatic perfusion index (HPI), blood flow (BF), blood volume (BV), mean transit time (MTT) and time to peak (TTP) between the reactive group and the non-responsive group after TACE. High preoperative ALP can predict the early effectiveness of liver cancer after TACE, but the more exact cut-off value of ALP needs further study.

Key words: CT perfusion imaging, hepatocellular carcinoma, post-TACE, Meta analysis

毕孝杨, 邱瑞珍, 杨福军, 范潇燕, 帅师, 唐艳隆. CT灌注成像对肝癌TACE术后早期反应预测价值的Meta分析[J]. 影像科学与光化学, 2023, 41(5): 260-269.

BI Xiaoyang, QIU Ruizhen, YANG Fujun, FAN Xiaoyan, SHUAI Shi, TANG Yanlong. The Value of Preoperative CT Perfusion Imaging in Predicting the Early Response of Hepatocellular Carcinoma after TACE: A Meta Analysis[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(5): 260-269.

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CT灌注成像对肝癌TACE术后早期反应预测价值的Meta分析

The Value of Preoperative CT Perfusion Imaging in Predicting the Early Response of Hepatocellular Carcinoma after TACE: A Meta Analysis

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