可溶性多氟烷氧基取代金属酞菁:新型肿瘤光动力治疗光敏剂

doi:10.7517/j.issn.1674-0475.2001.04.244

影像科学与光化学 ›› 2001, Vol. 19 ›› Issue (4): 244-249.DOI: 10.7517/j.issn.1674-0475.2001.04.244

可溶性多氟烷氧基取代金属酞菁:新型肿瘤光动力治疗光敏剂

高林东¹, 钱旭红², 张元兴³, 张立³

1. 华东理工大学药物化工研究所, 上海200237;
2. 大连理工大学精细化工国家重点实验室, 大连116012;
3. 华东理工大学生物反应器国家重点实验室, 上海200237

收稿日期:2001-08-06 修回日期:2001-08-22 出版日期:2001-11-20 发布日期:2001-11-20
通讯作者: 高林东(1966-), 男, 主要从事新药研究开发工作.
基金资助:
国家自然科学基金资助项目(批准号:29876009)

SOLUBLE FLUOROALKOXYL METAL PHTHALOCYANATE:NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC TUMOR THERAPY

GAO Lin-dong¹, QIAN Xu-hong², ZHANG Yuan-xing³, ZHANG Li³

1. Institute of Pesticides & Pharmaceuticals, East China University of Science & Technology, Shanghai 200237, P.R. China;
2. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, P.R. China;
3. State Key Laboratory of Bioreactors, East China University of Science & Technology, Shanghai 200237, P.R. China

Received:2001-08-06 Revised:2001-08-22 Online:2001-11-20 Published:2001-11-20

摘要/Abstract

摘要： 合成了9个新的多氟烷氧基取代的金属酞菁衍生物,它们均可溶于多数有机溶剂.光氧化能力和对DNA的光切断活性的研究表明,中心金属离子为锌和铝的酞菁衍生物,具有较好的产生单重态氧的能力.在乳化剂F8的存在下,锌酞菁衍生物2a对离体杂交瘤细胞表现出良好的光灭活作用.

关键词: 金属酞菁, 合成, 光敏剂, DNA光切断, 光细胞毒性

Abstract: Novel polyfluoroalkoxyl metal phthalocyanates were synthesized,which were soluble in most organic solvents.The photooxygenation and photocleavage to DNA showed that zinc and aluminum phthalocyanates have efficient action to generate singlet oxygen.2a in presence of emulsifying agent F68 displays a good photocytotoxicity in vitro on myeloma cells under the irradiation of red light.

Key words: phthalocyanine, synthesis, photosensitizer, DNA photocleavage, photocytotoxicity

中图分类号:

0644

高林东, 钱旭红, 张元兴, 张立. 可溶性多氟烷氧基取代金属酞菁:新型肿瘤光动力治疗光敏剂[J]. 影像科学与光化学, 2001, 19(4): 244-249.

GAO Lin-dong, QIAN Xu-hong, ZHANG Yuan-xing, ZHANG Li. SOLUBLE FLUOROALKOXYL METAL PHTHALOCYANATE:NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC TUMOR THERAPY[J]. Imaging Science and Photochemistry, 2001, 19(4): 244-249.

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可溶性多氟烷氧基取代金属酞菁:新型肿瘤光动力治疗光敏剂

SOLUBLE FLUOROALKOXYL METAL PHTHALOCYANATE:NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC TUMOR THERAPY

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