基于树状大分子的纳米CT成像造影剂的制备及其生物医学应用

doi:10.7517/j.issn.1674-0475.2013.02.001

摘要/Abstract

摘要： 树状大分子是一类高度支化的单分散性大分子,具有精确可控的分子结构.本文在树状大分子结构特点的基础上,阐述了以树状大分子为载体的新型纳米CT成像造影剂的合成及其在CT成像中的应用,并对树状大分子在CT成像中的发展趋势和应用领域进行了展望.

关键词: 树状大分子, 碘, 纳米金, 造影剂, CT成像

Abstract: Dendrimers are a family of highly branched, monodispersed synthetic macromolecules with well defined structural composition and architecture. Based on the unique structure of dendrimers, the synthesis and application of novel types of dendrimer-related CT imaging agents are reviewed in this article. Furthermore, future perspectives in the application and development of dendrimers-based CT imaging contrast agents are introduced.

Key words: dendrimer, iodine, gold nanopartices, contrast agents, CT imaging

中图分类号:

彭琛, 史向阳. 基于树状大分子的纳米CT成像造影剂的制备及其生物医学应用[J]. 影像科学与光化学, 2013, 31(2): 81-90.

PENG Chen, SHI Xiang-yang. Dendrimer-Based Nanoscale CT Contrast Agents: Preparation and Biomedical Applications[J]. Imaging Science and Photochemistry, 2013, 31(2): 81-90.

参考文献

[1] Peer D, Karp J M, Hong S, et al. Nanocarriers as an emerging platform for cancer therapy[J]. Nat. Nanotechnol., 2007, 2(12): 751-760.
[2] Moghimi S M, Hunter A C, Murray J C. Nanomedicine: current status and future prospects[J]. Faseb J., 2005, 19(3): 311-330.
[3] Tomalia D A, Baker H, Dewald J, et al. A new class of polymers: starburst-dendritic macromolecules[J]. Polym. J., 1985, 17(1): 117-132.
[4] Flory P J. Molecular size distribution in three dimensional polymers. I. gelation1 [J]. J. Am. Chem. Soc., 1941, 63(11): 3083-3090.
[5] Boas U, Christensen J B, Heegaard P M H. Dendrimers in Medicine and Biotechnology: New Molecular Tools[M]. Royal Society of Chemistry: 2006.
[6] Weissleder R. Molecular imaging: exploring the next frontier1 [J]. Radiology, 1999, 212(3): 609-614.
[7] Debbage P, Werner J. Molecular imaging with nanoparticles: giant roles for dwarf actors[J]. Histochem. Cell Biol., 2008, 130(5): 845-875.
[8] Deshpande N, Needles A, Willmann J K. Molecular ultrasound imaging: current status and future directions [J]. Clin. Radiol., 2010, 65(7): 567-581.
[9] Krause W. Delivery of diagnostic agents in computed tomography[J]. Adv. Drug Deliv. Rev.,1999, 37(1-3): 159-173.
[10] Haller C, Hizoh I. The cytotoxicity of iodinated radiocontrast agents on renal cells in vitro[J]. Invest. Radiol., 2004, 39(3): 149-154.
[11] Yordanov A T, Lodder A L, Woller E K, et al. Novel iodinated dendritic nanoparticles for computed tomography (CT) imaging[J]. Nano Lett., 2002, 2(6): 595-599.
[12] Yordanov A T, Mollov N, Lodder A L, et al. A water-soluble triiodo amino acid and its dendrimer conjugate for computerized tomography (CT) imaging[J]. J. Serb. Chem. Soc., 2005, 70(2): 163-170.
[13] Fu Y, Nitecki D E, Maltby D, et al. Dendritic iodinated contrast agents with PEG-cores for CT imaging: synthesis and preliminary characterization[J]. Bioconjugate Chem., 2006, 17(4): 1043-1056.
[14] Guo R, Wang H, Peng C, et al. Enhanced X-ray attenuation property of dendrimer-entrapped gold nanoparticles complexed with diatrizoic acid[J]. J. Mater. Chem., 2011, 18(13): 5120-5127.
[15] Guo R, Wang H, Peng C, et al. X-ray attenuation property of dendrimer-entrapped gold nanoparticles[J]. J. Phys. Chem. C, 2010, 114(1): 50-56.
[16] Peng C, Wang H, Guo R, et al. Acetylation of dendrimer-entrapped gold nanoparticles: synthesis, stability, and X-ray attenuation properties[J]. J. Appl. Polym. Sci., 2011, 119(3): 1673-1682.
[17] Peng C, Zheng L F, Chen Q, et al. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography[J]. Biomaterials, 2012, 33(4): 1107-1119.
[18] Wang H, Zheng L F, Peng C, et al. Computed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles[J]. Biomaterials, 2011, 32(11): 2979-2988.
[19] Knecht M R, Garcia-Martinez J C, Crooks R M. Hydrophobic dendrimers as templates for Au nanoparticles[J]. Langmuir, 2005, 21(25): 11981-11986.
[20] Oh S K, Kim Y G, Ye H C, et al. Synthesis, characterization, and surface immobilization of metal nanoparticles encapsulated within bifunctionalized dendrimers[J]. Langmuir, 2003, 19(24): 10420-10425.
[21] Shi X Y, Lee I, Baker J R Jr. Acetylation of dendrimer-entrapped gold and silver nanoparticles[J]. J. Mater. Chem., 2008, 18(5): 586-593.
[22] Shi X Y, Wang S H, Meshinchi S, et al. Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging[J]. Small, 2007, 3: 1245-1252.
[23] Shi X Y, Wang S H, Sun H P, et al. Improved biocompatibility of surface functionalized dendrimer entrapped gold nanoparticles[J]. Soft Matter, 2007, 3(1): 71-74.
[24] Crooks R M, Zhao M Q, Sun L, et al. Dendrimer-encapsulated metal nanoparticles: synthesis, characterization, and applications to catalysis[J]. Accounts Chem. Res., 2001, 34(3): 181-190.
[25] Balogh L, Tomalia D A. Poly(amidoamine) dendrimer-templated nanocomposites. 1. synthesis of zerovalent copper nanoclusters[J]. J. Am. Chem. Soc., 1998, 120(29): 7355-7356.
[26] Balogh L, Valluzzi R, Laverdure K S, et al. Formation of silver and gold dendrimer nanocomposites[J]. J. Nanoparticle Res., 1999, 1: 353-368.
[27] Lemon B I, Crooks R M. Preparation and characterization of dendrimer-encapsulated CdS semiconductor quantum dots[J]. J. Am. Chem. Soc., 2000, 122(51): 12886-12887.
[28] Wilson O M, Scott R W J, Garcia-Martinez J C, et al. Synthesis, characterization, and structure-selective extraction of 1-3-nm diameter AuAg dendrimer-encapsulated bimetallic nanoparticles[J]. J. Am. Chem. Soc., 2005, 127(3): 1015-1024.
[29] Esumi K. Dendrimers for nanoparticle synthesis and dispersion stabilization[J]. Colloid Chemistry II, 2003, 227: 31-52.
[30] Nalwa H S. Encyclopedia Nanoscience and Nanotechnology[M]. American Scientific Publisher, 2004. 2. 317-326.
[31] Esumi K, Suzuki A, Aihara N, et al. Preparation of gold colloids with UV irradiation using dendrimers as stabilizer[J]. Langmuir, 1998, 14(12): 3157-3159.
[32] Esumi K, Suzuki A, Yamahira A, et al. Role of poly(amidoamine) dendrimers for preparing nanoparticles of gold, platinum, and silver[J]. Langmuir., 2000, 16(6): 2604-2608.
[33] Fahmi A, Pietsch T, Appelhans D, et al. Water-soluble CdSe nanoparticles stabilised by dense-shell glycodendrimers[J]. New J. Chem., 2009, 33(4): 703-706.
[34] Shi X Y, Ganser T R, Sun K, et al. Characterization of crystalline dendrimer-stabilized gold nanoparticles[J]. Nanotechnology, 2006, 17(4): 1072-1078.
[35] Shi X Y, Sun K, Baker J R Jr. Spontaneous formation of functionalized dendrimer-stabilized gold nanoparticles[J]. J. Phys. Chem. C, 2008, 112(22): 8251-8258.
[36] Shi X Y, Sun K, Balogh L P, et al. Synthesis, characterization, and manipulation of dendrimer-stabilized iron sulfide nanoparticles[J]. Nanotechnology, 2006, 17(18): 4554-4560.
[37] Satoh N, Nakashima T, Kamikura K, et al. Quantum size effect in TiO₂ nanoparticles prepared by finely controlled metal assembly on dendrimer templates[J]. Nat. Nanotechnol., 2008, 3(2): 106-111.
[38] Goodson T, Varnavski O, Wang Y. Optical properties and applications of dendrimer-metal nanocomposites[J]. Int. Rev. Phys. Chem., 2004, 23(1): 109-150.
[39] Wu X C, Bittner A M, Kern K. Synthesis, photoluminescence, and adsorption of CdS/dendrimer nanocomposites[J]. J. Phys. Chem. B, 2005, 109(1): 230-239.
[40] Kojima C, Umeda Y, Ogawa M, et al. X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer[J]. Nanotechnology, 2010, 21(24): 245104.
[41] Liu H, Wang H, Guo R, et al. Size-controlled synthesis of dendrimer-stabilized silver nanoparticles for X-ray computed tomography imaging applications[J]. Polym. Chem., 2010, 1(10): 1677-1683.
[42] Liu H, Shen M W, Zhao J, et al. Tunable synthesis and acetylation of dendrimer-entrapped or dendrimer-stabilized gold-silver alloy nanoparticles[J]. Colloid Surf. B-Biointerfaces, 2012, 94: 58-67.
[43] Liu H, Sun K, Zhao J L, et al. Dendrimer-mediated synthesis and shape evolution of gold-silver alloy nanoparticles[J]. Colloid Surf. A-Physicochem. Eng. Asp., 2012, 405: 22-29.
[44] Regino C A S, Walbridge S, Bernardo M, et al. A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents[J]. Contrast Media Mol. Imaging, 2008, 3(1): 2-8.
[45] Cai H, Li K, Shen M, et al. Facile assembly of Fe₃O₄@ Au nanocomposite particles for dual mode magnetic resonance and computed tomography imaging applications[J]. J. Mater. Chem., 2012, 22(30): 15110-15120.
[46] Shukla R, Hill E, Shi X Y, et al. Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles[J]. Soft Matter, 2008, 4(11): 2160-2163.