Abstract: This study explored the correlation between endometrial blood flow parameters and β-human chorionic gonadotropin (β-hCG), vascular endothelial growth factor (VEGF) and the diagnostic value of early ectopic pregnancy. 176 cases of suspected early ectopic pregnancy were selected, and according the diagnostic curettage examination as the gold standard 86 cases of early ectopic pregnancy were confirmed as the study group, and 90 cases of early ectopic pregnancy were excluded as the control group. Comparing endometrial flow parameters, and diastolic velocity (VD), maximum systolic velocity (VS), resistance index (RI), β-hCG, and VEGF levels and their correlation in different disease severity. Compared with mild ectopic pregnancy, the VS, VD, RI, and VEGF increased in order, β-hCG decreased in order for patients with moderate and severe ectopic pregnancy. VS, VD, RI, VEGF were positively correlated with the severity of the disease, while β-hCG was negatively correlated with the severity of the disease. The sensitivity, specificity and AUC of VS, VD and RI combined in the diagnosis of ectopic pregnancy were 98.84%, 83.33% and 0.937, respectively. And the diagnostic value of combined examination was higher than that of single examination (P<0.05). Combined detection of endometrial blood flow parameters, β-hCG and VEGF is beneficial for the diagnosis of early ectopic pregnancy, and VS, VD, RI are correlated with β-hCG and VEGF.

Key words: endometrial blood flow parameters, β-human chorionic gonadotropin, vascular endothelial growth factor, ectopic pregnancy