DECT心肌灌注成像联合血清ANXA1诊断心肌梗死的研究

doi:10.7517/issn.1674-0475.220320

摘要/Abstract

摘要： 考察双源双能量CT （DECT）心肌灌注成像联合血清膜联蛋白A1（ANXA1）诊断心肌梗死的价值。将100例接受DECT心肌灌注成像检查的可疑心肌梗死患者纳入本研究。使用德国西门子大螺距双源双能量CT仪对患者进行检查，通过酶联免疫吸附（ELISA）试剂盒检测血清ANXA1水平。以冠状动脉造影和临床资料为金标准，共诊断出55例为心肌梗死，45例为非心肌梗死。DECT诊断心肌梗死的敏感性、特异性分别为92.73%、88.89%。心肌梗死患者血清ANXA1的水平显著低于非心肌梗死患者（t=6.582，P<0.001）。血清ANXA1诊断心肌梗死的敏感性和特异性分别为92.73%和68.89%。以血清ANXA1水平≤1.92 ng/mL为阳性指标或DECT诊断结果阳性为阳性，DECT联合血清ANXA1诊断心肌梗死的敏感性和特异性分别为99.47%和61.24%。DECT联合血清ANXA1可有效提高心肌梗死的诊断敏感性，降低漏诊率，具有较高的临床使用潜在价值。

关键词: 心肌梗死, 双源双能量CT, 膜联蛋白A1, 血清学指标, 敏感性, 漏诊率

Abstract: This study investigated the value of dual-source dual-energy CT (DECT) myocardial perfusion imaging combined with serum annexin A1 (ANXA1) in the diagnosis of myocardial infarction. 100 patients with suspected myocardial infarction who underwent DECT myocardial perfusion were selected. All patients were examined with a German Siemens large-pitch dual-source dual-energy CT scanner, and the serum ANXA1 level was detected by an enzyme-linked immunosorbent (ELISA) kit. The coronary angiography and clinical data were used as the gold standard, 55 cases were diagnosed as myocardial infarction and 45 cases as non-myocardial infarction. The sensitivity and specificity of DECT for the diagnosis of myocardial infarction were 92.73% and 88.89%, respectively. The level of serum ANXA1 in patients with myocardial infarction was significantly lower than that in patients without myocardial infarction (t=6.582,P<0.001). The sensitivity and specificity of serum ANXA1 for the diagnosis of myocardial infarction were 92.73% and 68.89%, respectively. With the combined diagnosis based on serum ANXA1 level ≤ 1.92 ng/mL as a positive index or a positive DECT diagnosis result, the sensitivity and specificity of DECT combined with serum ANXA1 for the diagnosis of myocardial infarction were 99.47% and 61.24%, respectively. DECT combined with serum ANXA1 can effectively improve the diagnostic sensitivity of myocardial infarction, also could reduce the missed diagnosis rate, and has a high potential clinical value.

Key words: myocardial infarction, dual-source dual-energy CT, annexin A1, serological index, sensitivity, missed diagnosis rate

罗薇, 张晶, 李茜. DECT心肌灌注成像联合血清ANXA1诊断心肌梗死的研究[J]. 影像科学与光化学, 2022, 40(5): 1133-1137.

LUO Wei, ZHANG Jing, LI Qian. Study of DECT Myocardial Perfusion Imaging Combined with Serum ANXA1 in the Diagnosis of Myocardial Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1133-1137.

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