急性脑梗死患者的磁共振弥散峰度成像参数变化及与血清miR-181c、miR-210水平变化的相关性分析

doi:10.7517/issn.1674-0475.201205

摘要/Abstract

摘要： 本研究探讨急性脑梗死患者磁共振弥散峰度成像（DKI）参数变化及与血清微小RNA（miR）-181c、miR-120水平的相关性及意义。选取急性脑梗死患者155例（观察组），同时选取体检健康者100例作为对照组，检测两组血清miR-181c、miR-210水平，采用观察组给予MRI检查，分析平均峰度（MK）、径向峰度（RK）、轴向峰度（AK）、轴向张量（AD）、平均扩散系数（MD）和径向张量（RD）。实验结果显示：观察组血清miR-181c相对表达量明显高于对照组（P<0.05），而miR-120相对表达量明显低于对照组（P<0.05）；观察组患者病变侧MK、RK和AK明显高于对照侧（P<0.05），而AD、MD和RD明显低于对照侧（P<0.05）；多元线性回归分析结果显示：miR-181c相对表达量、miR-210相对表达量、MK、RK、AK是NIHSS评分的影响因素（P<0.05）。研究证实：急性脑梗死患者DKI参数与血清miR-181c呈正相关，与miR-210呈负相关，与患者神经缺损程度有一定关系。

关键词: 急性脑梗死, 磁共振弥散峰度成像, miR-181c, miR-120, 相关性

Abstract: The purpose of this study was to investigate the correlation and significance of diffusion kurtosis imaging (DKI) parameters and serum microRNA (miR)-181c, miR-120 levels in patients with acute cerebral infarction. A total of 155 patients with acute cerebral infarction were selected as observation group and 100 healthy people were selected as control group. The levels of serum miR-181c and miR-210 in the two groups were detected, the MRI examination was performed in the observation group, mean kurtosis (MK), radial kurtosis (RK), axial kurtosis (AK), axial diffusion (AD) and mean diffusion (MD) and radial diffusion (RD) were analyzed. The experimental results showed that:The relative expression of miR-181c in the observation group was significantly higher than that in the control group (P<0.05), while the relative expression of miR-120 in the observation group was significantly lower than that in the control group (P<0.05). The MK, RK and AK in the lesion side of the observation group were significantly higher than those in the control side (P<0.05), while those of AD, MD and RD in the observation group were significantly lower than those in the control side (P<0.05). miR-181c was positively correlated with MK and RK (P<0.05), while miR-210 was negatively correlated with AK (P<0.05). Multiple linear regression analysis showed that the relative expression of miR-181c, miR-210, MK, RK, AK were the influencing factors of NIHSS score (P<0.05). This study confirmed that:In patients with acute cerebral infarction, MRI DKI parameters are positively correlated with serum miR-181c, negatively correlated with miR-210, and to some extent with the degree of nerve defect in patients.

Key words: acute cerebral infarction, magnetic resonance diffusion kurtosis imaging, miR-181c, miR-120, the correlation

张宇峰, 刘艳武. 急性脑梗死患者的磁共振弥散峰度成像参数变化及与血清miR-181c、miR-210水平变化的相关性分析[J]. 影像科学与光化学, 2021, 39(5): 754-759.

ZHANG Yufeng, LIU Yanwu. Correlation between MR Diffusion Kurtosis Imaging Parameters and Serum miR-181c, miR-210 Levels in Patients with Acute Cerebral Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 754-759.

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