增强CT联合血清指标诊断结直肠癌的价值

doi:10.7517/issn.1674-0475.210726

摘要/Abstract

摘要： 本文探讨癌胚抗原（CEA）、糖类抗原19-9（CA19-9）、胰岛素样生长因子结合蛋白-3（IGFBP-3）及增强CT在结直肠癌中的联合诊断效果。选取100例结直肠癌患作为观察组，同时选取结直肠良性肿瘤患者60例作为对照组，检测血清CEA、CA19-9、IGFBP-3，同时给予增强CT检查。观察组血清CEA和CA19-9高于对照组（P<0.05），而IGFBP-3低于对照组（P<0.05）；TNM分期Ⅲ～Ⅳ和Ⅰ～Ⅱ患者血清CEA、CA19-9和IGFBP-3差异比较有统计学意义（P<0.05）；增强CT联合血清指标联合诊断灵敏性为89.00%、特异性为90.00%；增强CT诊断结直肠癌T分期、N分期与病理结果Kappa值分别为0.696和0.790（P<0.05）。CEA、CA19-9、IGFBP-3联合增强CT是一种具有较高效能的结直肠癌诊断方法。

关键词: 癌胚抗原, 糖类抗原19-9, 胰岛素样生长因子结合蛋白-3, 增强CT, 结直肠癌

Abstract: The purpose of this study was to explore the value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), insulin-like growth factor binding protein-3 (IGFBP-3) combined with enhanced CT in the diagnosis of colorectal cancer. 100 patients with colorectal cancer were selected as observation group and 60 patients with colorectal benign tumor were selected as the control group, the serum CEA, CA19-9 and IGFBP-3 were detected and enhanced CT was performed. The serum CEA and CA19-9 in the observation group were higher than those in the control group (P<0.05), while IGFBP-3 was lower than those in the control group (P<0.05). There were statistically significant differences in serum CEA, CA19-9 and IGFBP-3 in TNM staging Ⅲ-Ⅳ and Ⅰ-Ⅱ patients (P<0.05). The sensitivity and specificity of enhanced CT combined with serum index were 89.00% and 90.00% respectively. The Kappa value of contrast-enhanced CT in the diagnosis of colorectal cancer T and N staging and pathological results was 0.696 and 0.790 (P<0.05). The combination of CEA, CA19-9 and IGFBP-3 enhanced CT has a good value in the diagnosis of colorectal cancer and is worth clinical use.

Key words: carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), insulin-like growth factor binding protein-3(IGFBP-3), enhanced CT, colorectal cancer

蔡丽, 全祥. 增强CT联合血清指标诊断结直肠癌的价值[J]. 影像科学与光化学, 2022, 40(1): 43-47.

CAI Li, QUAN Xiang. The Value of Enhanced CT Combined with Serum Markers in the Diagnosis of Colorectal Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(1): 43-47.

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