Abstract: This article explored the application value of dual-source CT (DSCT) combined with miR-10b-3p in the diagnosis of carotid artery stenosis in patients with ischemic stroke. A total of 133 patients with confirmed acute ischemic stroke were selected as the research objects. All patients underwent DSCT examination, and the stenosis rate and calcification were measured. Serum miR-10b-3p levels of patients were detected by RT-qPCR. The results showed that the AUC of DSCT for diagnosing 50% stenosis was 0.995, the sensitivity was 100.00%, and the specificity was 94.20%. With the increase of stenosis rate, the level of serum miR-10b-3p decreased gradually (P<0.05). Compared with the soft plaque group and the fibrous plaque group, the serum miR-10b-3p level in the calcified plaque group was significantly lower (P<0.05). The AUC of serum miR-10b-3p for diagnosing calcified plaque was 0.823. The AUC of miR-10b-3p for the diagnosis of 50% carotid artery stenosis was 0.815. The AUC, sensitivity and specificity of DSCT combined with miR-10b-3p in the diagnosis of 50% carotid stenosis were 0.995, 100.00% and 94.20%, respectively. DSCT has high diagnostic value for carotid artery stenosis in patients with stroke. Serum miR-10b-3p can be used as an auxiliary index for DSCT to detect carotid artery stenosis and a biomarker for carotid plaque formation.

Key words: ischemic stroke, dual-source CT, carotid artery stenosis, miR-10b-3p, calcified plaque