IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (6): 1596-1601.DOI: 10.7517/issn.1674-0475.220811

• Review and Articles • Previous Articles     Next Articles

Application of Dual-source CT Combined with miR-10b-3p in the Diagnosis of Stroke Carotid Artery Stenosis

SI Yandong1, CHEN Kuntao1, LIU Liang2, PENG Xinghui2   

  1. 1. Department of Radiology, The Fifth Affiliated Hospital(Zhuhai) of Zunyi Medical University, Zhuhai 519100, Guangdong, P. R. China;
    2. Department of Radiology, Doumen Hospital, Guangdong Provincial Hospital of Chinese Medicine(Zhuhai Doumen District Qiaoli Hospital of Traditional Chinese Medicine), Zhuhai 519125, Guangdong, P. R. China
  • Received:2022-08-08 Online:2022-11-23 Published:2022-11-15

Abstract: This article explored the application value of dual-source CT (DSCT) combined with miR-10b-3p in the diagnosis of carotid artery stenosis in patients with ischemic stroke. A total of 133 patients with confirmed acute ischemic stroke were selected as the research objects. All patients underwent DSCT examination, and the stenosis rate and calcification were measured. Serum miR-10b-3p levels of patients were detected by RT-qPCR. The results showed that the AUC of DSCT for diagnosing 50% stenosis was 0.995, the sensitivity was 100.00%, and the specificity was 94.20%. With the increase of stenosis rate, the level of serum miR-10b-3p decreased gradually (P<0.05). Compared with the soft plaque group and the fibrous plaque group, the serum miR-10b-3p level in the calcified plaque group was significantly lower (P<0.05). The AUC of serum miR-10b-3p for diagnosing calcified plaque was 0.823. The AUC of miR-10b-3p for the diagnosis of 50% carotid artery stenosis was 0.815. The AUC, sensitivity and specificity of DSCT combined with miR-10b-3p in the diagnosis of 50% carotid stenosis were 0.995, 100.00% and 94.20%, respectively. DSCT has high diagnostic value for carotid artery stenosis in patients with stroke. Serum miR-10b-3p can be used as an auxiliary index for DSCT to detect carotid artery stenosis and a biomarker for carotid plaque formation.

Key words: ischemic stroke, dual-source CT, carotid artery stenosis, miR-10b-3p, calcified plaque