子宫内膜血流参数联合β-hCG和VEGF在早期异位妊娠诊断中的应用

doi:10.7517/issn.1674-0475.220128

摘要/Abstract

摘要： 本文探究子宫内膜血流参数与β-人绒毛膜促性腺激素（β-hCG）、血管内皮生长因子（VEGF）的相关性及对早期异位妊娠的诊断价值。选取176例疑似早期异位妊娠患者，以诊断性刮宫检查结果为金标准，86例确诊早期异位妊娠患者作为研究组，90例排除早期异位妊娠患者作为对照组。对比两组子宫内膜血流参数，比较不同病情严重程度舒张末期流速（VD）、收缩期最大血流速度（VS）、阻力指数（RI）、β-hCG、VEGF水平及其相关性。与轻度异位妊娠患者相比，中度、重度异位妊娠患者VS、VD、RI、VEGF水平依次升高，β-hCG水平依次下降；VS、VD、RI、VEGF与病情严重程度呈正相关，β-hCG与病情严重程度呈负相关；VS、VD和RI联合诊断异位妊娠的灵敏度为98.84%，特异度为83.33%，AUC为0.937，联合检测的诊断价值高于单一检测（P<0.05）。子宫内膜血流参数、β-hCG、VEGF联合检测有利于对异位妊娠的早期诊断，VS、VD、RI与β-hCG、VEGF具有相关性。

关键词: 子宫内膜血流参数, β-人绒毛膜促性腺激素, 血管内皮生长因子, 异位妊娠

Abstract: This study explored the correlation between endometrial blood flow parameters and β-human chorionic gonadotropin (β-hCG), vascular endothelial growth factor (VEGF) and the diagnostic value of early ectopic pregnancy. 176 cases of suspected early ectopic pregnancy were selected, and according the diagnostic curettage examination as the gold standard 86 cases of early ectopic pregnancy were confirmed as the study group, and 90 cases of early ectopic pregnancy were excluded as the control group. Comparing endometrial flow parameters, and diastolic velocity (VD), maximum systolic velocity (VS), resistance index (RI), β-hCG, and VEGF levels and their correlation in different disease severity. Compared with mild ectopic pregnancy, the VS, VD, RI, and VEGF increased in order, β-hCG decreased in order for patients with moderate and severe ectopic pregnancy. VS, VD, RI, VEGF were positively correlated with the severity of the disease, while β-hCG was negatively correlated with the severity of the disease. The sensitivity, specificity and AUC of VS, VD and RI combined in the diagnosis of ectopic pregnancy were 98.84%, 83.33% and 0.937, respectively. And the diagnostic value of combined examination was higher than that of single examination (P<0.05). Combined detection of endometrial blood flow parameters, β-hCG and VEGF is beneficial for the diagnosis of early ectopic pregnancy, and VS, VD, RI are correlated with β-hCG and VEGF.

Key words: endometrial blood flow parameters, β-human chorionic gonadotropin, vascular endothelial growth factor, ectopic pregnancy

李琦, 汪俊, 梅春秀. 子宫内膜血流参数联合β-hCG和VEGF在早期异位妊娠诊断中的应用[J]. 影像科学与光化学, 2022, 40(4): 912-916.

LI Qi, WANG Jun, MEI Chunxiu. Application of Endometrial Blood Flow Parameters Combined with β-hCG and VEGF in the Diagnosis of Early Ectopic Pregnancy[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 912-916.

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