DSCT联合miR-10b-3p在脑卒中颈动脉狭窄诊断中的应用

doi:10.7517/issn.1674-0475.220811

摘要/Abstract

摘要： 本文探讨双源CT(DSCT)联合miR-10b-3p在缺血性脑卒中患者颈动脉狭窄诊断中的应用价值。选择133例确诊为急性缺血性脑卒中患者作为研究对象,所有患者均进行了DSCT检查,测量狭窄率和钙化情况。通过RT-qPCR检测患者血清miR-10b-3p水平。结果显示,DSCT诊断50%狭窄的AUC为0.995,敏感性为100.00%,特异性为94.20%。随着狭窄率的升高,血清miR-10b-3p水平呈逐渐降低的趋势(P<0.05)。与软斑块组和纤维斑块组比较,钙化斑块组患者的血清miR-10b-3p水平显著降低(P<0.05)。血清miR-10b-3p诊断钙化斑块的AUC为0.823。miR-10b-3p诊断50%颈动脉狭窄的AUC为0.815。DSCT联合miR-10b-3p诊断50%颈动脉狭窄的AUC、敏感性和特异性分别为0.995、100.00%和94.20%。DSCT对脑卒中患者颈动脉狭窄的诊断价值高,血清miR-10b-3p可作为DSCT检查颈动脉狭窄的辅助指标,可作为颈动脉斑块形成的生物标志物。

关键词: 缺血性脑卒中, 双源CT, 颈动脉狭窄, miR-10b-3p, 钙化斑块

Abstract: This article explored the application value of dual-source CT (DSCT) combined with miR-10b-3p in the diagnosis of carotid artery stenosis in patients with ischemic stroke. A total of 133 patients with confirmed acute ischemic stroke were selected as the research objects. All patients underwent DSCT examination, and the stenosis rate and calcification were measured. Serum miR-10b-3p levels of patients were detected by RT-qPCR. The results showed that the AUC of DSCT for diagnosing 50% stenosis was 0.995, the sensitivity was 100.00%, and the specificity was 94.20%. With the increase of stenosis rate, the level of serum miR-10b-3p decreased gradually (P<0.05). Compared with the soft plaque group and the fibrous plaque group, the serum miR-10b-3p level in the calcified plaque group was significantly lower (P<0.05). The AUC of serum miR-10b-3p for diagnosing calcified plaque was 0.823. The AUC of miR-10b-3p for the diagnosis of 50% carotid artery stenosis was 0.815. The AUC, sensitivity and specificity of DSCT combined with miR-10b-3p in the diagnosis of 50% carotid stenosis were 0.995, 100.00% and 94.20%, respectively. DSCT has high diagnostic value for carotid artery stenosis in patients with stroke. Serum miR-10b-3p can be used as an auxiliary index for DSCT to detect carotid artery stenosis and a biomarker for carotid plaque formation.

Key words: ischemic stroke, dual-source CT, carotid artery stenosis, miR-10b-3p, calcified plaque

司延栋, 陈昆涛, 刘亮, 彭兴慧. DSCT联合miR-10b-3p在脑卒中颈动脉狭窄诊断中的应用[J]. 影像科学与光化学, 2022, 40(6): 1596-1601.

SI Yandong, CHEN Kuntao, LIU Liang, PENG Xinghui. Application of Dual-source CT Combined with miR-10b-3p in the Diagnosis of Stroke Carotid Artery Stenosis[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1596-1601.

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