The Value of Preoperative CT Perfusion Imaging in Predicting the Early Response of Hepatocellular Carcinoma after TACE: A Meta Analysis

doi:10.7517/issn.1674-0475.230608

Abstract

Abstract: To systematically evaluate the predictive value of preoperative computed tomography perfusion imaging (CTPI) parameters in early response to transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). The relationship between CT perfusion imaging and TACE prognosis was searched in China knowledge Network, Wanfang, VIP, PubMed, Medline, Web of Science and Embase databases by computer. Meta analysis was carried out by using RevMan 5.4 software. The mean difference (MD) was used, and each effect was expressed by 95% confidence interval (CI). A total of 7 articles were included, including 433 patients with a total of 475 tumor lesions. Meta analysis showed that there was significant difference in arterial liver perfusion (ALP) between the reactive group and the non-responsive group after TACE (MD=16.84,95%CI 2.06~31.62, P<0.05). The ALP of reactive group was significantly higher than that of non-responsive group, and the 260best cut-off value range was 9.885~22.175 mL/ (100 mL ·min). There was no significant difference in portal venous liver perfusion (PVP), hepatic perfusion index (HPI), blood flow (BF), blood volume (BV), mean transit time (MTT) and time to peak (TTP) between the reactive group and the non-responsive group after TACE. High preoperative ALP can predict the early effectiveness of liver cancer after TACE, but the more exact cut-off value of ALP needs further study.

Key words: CT perfusion imaging, hepatocellular carcinoma, post-TACE, Meta analysis

BI Xiaoyang, QIU Ruizhen, YANG Fujun, FAN Xiaoyan, SHUAI Shi, TANG Yanlong. The Value of Preoperative CT Perfusion Imaging in Predicting the Early Response of Hepatocellular Carcinoma after TACE: A Meta Analysis[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(5): 260-269.

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